Correlation between Electrocardiogram Changes and Right Ventricular Systolic Function in Patients with Chronic Atrial Fibrillation

Authors

  • Ling Yang Electrical Physiology Department, Yantaishan Hospital, 264000 Yantai, Shandong, China
  • Rong Yan Electrical Physiology Department, Yantaishan Hospital, 264000 Yantai, Shandong, China

DOI:

https://doi.org/10.59958/hsf.7355

Keywords:

chronic atrial fibrillation, right ventricular contraction, electrocardiogram, ultrasonic diagnosis

Abstract

Background: Chronic atrial fibrillation (CAF) induces various electric disturbances, and a single mutation can cause multifarious phenotypes or combinations. Identifying the correlation of electrocardiogram changes corresponding to the disorders of electrical activity with right ventricular systolic function (RVSF) is important for the treatment and prognosis of CAF. Therefore, this study explored the correlation of electrocardiogram changes and RVSF in patients with CAF. Methods: From March 2022, to March 2023, 97 patients with CAF admitted to the Department of Cardiology of our hospital (study group) and 100 normal people who received health examination (control group) were subjected to echocardiogram and electrocardiogram to record relevant parameters for correlation analysis. Results: Significant differences were found in the electrocardiogram indices and right heart function parameters between the two groups. The study group had significantly higher heart rate, QTc interval, QT interval and T wave time than the control group (p < 0.05). The study group showed significantly higher right ventricular end-diastolic volume (RVEDV) and right ventricular end-systolic volume (RVESV), and lower right ventricular stroke volume (RVSV) and right ventricular ejection fraction (RVEF) than the control group (p < 0.05). Pearson correlation analysis showed that QTc interval, QT interval, and T wave time were positively correlated with RVESV (p < 0.05); QTc interval, QT interval, and T wave time were negatively correlated with RVSV (p < 0.05); and QTc interval was negatively correlated with RVEF (p < 0.05). Conclusion: A correlation exists between electrocardiogram changes and RVSF in patients with CAF.

References

Russo V, Attena E, Di Maio M, Mazzone C, Carbone A, Parisi V, et al. Clinical profile of direct oral anticoagulants versus vitamin K anticoagulants in octogenarians with atrial fibrillation: a multicentre propensity score matched real-world cohort study. Journal of Thrombosis and Thrombolysis. 2020; 49: 42–53.

Kaasenbrood F, Hollander M, de Bruijn SH, Dolmans CP, Tieleman RG, Hoes AW, et al. Opportunistic screening versus usual care for diagnosing atrial fibrillation in general practice: a cluster randomised controlled trial. The British Journal of General Practice. 2020; 70: e427–e433.

Jin X, Pan J, Wu H, Xu D. Are left ventricular ejection fraction and left atrial diameter related to atrial fibrillation recurrence after catheter ablation?: A meta-analysis. Medicine. 2018; 97: e10822.

Grzeczka A, Graczyk S, Kordowitzki P. DNA Methylation and Telomeres-Their Impact on the Occurrence of Atrial Fibrillation during Cardiac Aging. International Journal of Molecular Sciences. 2023; 24: 15699.

Helmy KM, Biomy R, Salama MK, Haseeb WA. Left Atrial Function Assessment By Speckle Tracking Echocardiography In Low-Risk Atrial Fibrillation Patients. The Journal of the Pakistan Medical Association. 2023; 73: S142–S145.

Odeh A, Dungan GD, Hoppensteadt D, Siddiqui F, Kantarcioglu B, Darki A, et al. Interrelationship Between Inflammatory Biomarkers and Collagen Remodeling Proteins in Atrial Fibrillation. Clinical and Applied Thrombosis/Hemostasis. 2023; 29: 10760296231165055.

Vitarelli A, Mangieri E, Gaudio C, Tanzilli G, Miraldi F, Capotosto L. Right atrial function by speckle tracking echocardiography in atrial septal defect: Prediction of atrial fibrillation. Clinical Cardiology. 2018; 41: 1341–1347.

Gilon C, Grégoire JM, Mathieu M, Carlier S, Bersini H. IRIDIA-AF, a large paroxysmal atrial fibrillation long-term electrocardiogram monitoring database. Scientific Data. 2023; 10: 714.

Machino T, Aonuma K, Komatsu Y, Yamasaki H, Igarashi M, Nogami A, et al. Dry textile electrode for ambulatory monitoring after catheter ablation of atrial fibrillation: A pilot study of simultaneous comparison to the Holter electrocardiogram. F1000Research. 2022; 11: 97.

World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA. 2013; 310: 2191–2194.

Writing Committee Members, Joglar JA, Chung MK, Armbruster AL, Benjamin EJ, Chyou JY, et al. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Journal of the American College of Cardiology. 2024; 83: 109–279.

Chinese Society of Cardiology, Chinese Society of Biomedical Engineering. Chinese guidelines for the diagnosis and treatment of atrial fibrillation. Chinese Journal of Cardiology. 2023; 51: 572–618.

Seifert MB, Olesen MS, Christophersen IE, Nielsen JB, Carlson J, Holmqvist F, et al. Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early-onset lone atrial fibrillation. Annals of Noninvasive Electrocardiology. 2019; 24: e12661.

Siwaponanan P, Kaewkumdee P, Phromawan W, Udompunturak S, Chomanee N, Udol K, et al. Increased expression of six-large extracellular vesicle-derived miRNAs signature for nonvalvular atrial fibrillation. Journal of Translational Medicine. 2022; 20: 4.

Donniacuo M, De Angelis A, Telesca M, Bellocchio G, Riemma MA, Paolisso P, et al. Atrial fibrillation: Epigenetic aspects and role of sodium-glucose cotransporter 2 inhibitors. Pharmacological Research. 2023; 188: 106591.

Chung CC, Chin CG, Lin YK, Chen YC, Cheng WL, Yeh YH, et al. Regional Diversities in Fibrogenesis Weighed as a Key Determinant for Atrial Arrhythmogenesis. Biomedicines. 2021; 9: 1900.

Wu ZS, Xue J, Mu YM, Maimaiti A. Evaluation of right ventricular function in patients with atrial fibrillation by real-time three-dimensional echocardiography and speckle tracking imaging. China Medicine Review. 2012; 19: 151–155. (In Chinese)

Wang Q, Chen Y, Zhang D, Li C, Chen X, Hou J, et al. Activin Receptor-Like Kinase 4 Haplodeficiency Mitigates Arrhythmogenic Atrial Remodeling and Vulnerability to Atrial Fibrillation in Cardiac Pathological Hypertrophy. Journal of the American Heart Association. 2018; 7: e008842.

Ramos-Mondragón R, Lozhkin A, Vendrov AE, Runge MS, Isom LL, Madamanchi NR. NADPH Oxidases and Oxidative Stress in the Pathogenesis of Atrial Fibrillation. Antioxidants. 2023; 12: 1833.

Published

2024-05-19

How to Cite

Yang, L., & Yan, R. (2024). Correlation between Electrocardiogram Changes and Right Ventricular Systolic Function in Patients with Chronic Atrial Fibrillation. The Heart Surgery Forum, 27(5), E528-E532. https://doi.org/10.59958/hsf.7355

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