Mitral Annular Remodeling to Treat Functional Mitral Regurgitation: A Pilot Acute Study in a Canine Model

Authors

  • Hideyuki Fumoto
  • Tohru Takaseya
  • Akira Shiose
  • Roberto M. Saraiva
  • Yoko Arakawa
  • Margaret Park
  • Santosh Rao
  • Raymond Dessoffy
  • Ji-Feng Chen
  • Qun Zhou
  • Anthony Calabro
  • Michael Banbury
  • Kiyotaka Fukamachi

DOI:

https://doi.org/10.1532/HSF98.20101003

Abstract

Background: The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR).

Methods: Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection.

Results: The injection improved MR grade from 3.4 ± 0.8 to 1.3 ± 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 ± 0.4 cm to 2.9 ± 0.3 cm; P = .039) and MR volume (20.6 ± 7.3 mm3 to 5.2 ± 2.2 mm3; P = .044).

Conclusions: A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model.

References

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Published

2010-08-18

How to Cite

Fumoto, H., Takaseya, T., Shiose, A., Saraiva, R. M., Arakawa, Y., Park, M., Rao, S., Dessoffy, R., Chen, J.-F., Zhou, Q., Calabro, A., Banbury, M., & Fukamachi, K. (2010). Mitral Annular Remodeling to Treat Functional Mitral Regurgitation: A Pilot Acute Study in a Canine Model. The Heart Surgery Forum, 13(4), E247-E250. https://doi.org/10.1532/HSF98.20101003

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Section

Articles