Effects of Off-Pump Versus On-Pump Coronary Artery Bypass Grafting: Apoptosis, Inflammation, and Oxidative Stress

Authors

  • Murat Bicer
  • Tunay Senturk
  • Murat Yanar
  • Ahmet Tutuncu
  • Arzu Yilmaztepe Oral
  • Engin Ulukaya
  • Zehra Serdar
  • Işık Senkaya Signak

DOI:

https://doi.org/10.1532/HSF98.2014326

Abstract

Background: It has been suggested that off-pump coronary
artery bypass grafting (CABG) surgery reduces myocardial
ischemia-reperfusion injury, postoperative systemic
inflammatory response, and oxidative stress. The aim of this
study was to measure serum malondialdehyde (MDA), highsensitivity
C-reactive protein (hs-CRP), M30, and M65 levels
and to investigate the relationship between M30 levels and
oxidative stress and inflammation in patients undergoing onand
off-pump CABG surgery.
Methods: Fifty patients were randomly assigned to onpump
or off-pump CABG surgery (25 patients off-pump and
25 on-pump CABG surgery), and blood samples were collected
prior to surgery, and 30 minutes, 60 minutes, 6 hours,
and 24 hours after CABG surgery.
Results: Compared to the on-pump group, serum MDA
levels at 30 minutes, 60 minutes, 6 hours, and 24 hours after
the CABG surgery were significantly lower in the off-pump
group (P = .001, P = .001, P = .001, and P = .001, respectively).
Serum M30 levels were found to be elevated in both groups,
returning to baseline at 24 hours. When compared to baseline,
the hs-CRP level reached its peak at 24 hours at 13.28 ±
5.32 mg/dL in the on-pump group, and 15.44 ± 4.02 mg/dL
in the off-pump group.
Conclusion: CABG surgery is associated with an increase
in inflammatory markers and serum M30 levels, indicating
epithelial/endothelial apoptosis in the early period.

Published

2014-11-03

How to Cite

Bicer, M., Senturk, T., Yanar, M., Tutuncu, A., Oral, A. Y., Ulukaya, E., Serdar, Z., & Signak, I. S. (2014). Effects of Off-Pump Versus On-Pump Coronary Artery Bypass Grafting: Apoptosis, Inflammation, and Oxidative Stress. The Heart Surgery Forum, 17(5), E271-E276. https://doi.org/10.1532/HSF98.2014326

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