Retrospective Analysis of Surgically Treated Infective Endocarditis Cases


  • Oktay Burma
  • Cem Atik
  • M. Adnan Celkan
  • Ha?im Üstünsoy
  • Hakki Kazaz



Background. Prosthetic valve endocarditis (PVE) and native valve endocarditis (NVE) both cause high rates of morbidity and mortality and are significant health problems in our community. Optimal timing of the surgical intervention depends on the hemodynamic stability of the patient. In the present study, we retrospectively evaluated the clinical status, bacteriology, morbidity, and mortality parameters of infective endocarditis cases that were treated surgically.

Methods. Thirty patients (20 male and 10 female) who underwent cardiac valve surgery between April 2001 and December 2006 were included in the study. The mean (SD) age of the patients was 36.5 ± 5.42 years. Thirty-five surgical operations were conducted on 30 patients. We evaluated the patient demographic, etiologic, and surgical data retrospectively with respect to mortality and morbidity.

Results. The mean time to develop PVE was 13 months. We recorded a mortality rate of 16.6% (2 deaths in NVE operations and 3 deaths in PVE operations). Repeat surgeries were performed in 2 aortic valve cases and 3 mitral valve cases in which paravalvular leakage was noticed in the prosthetic valves.

Conclusion. Despite significant medical and surgical advances, both NVE and PVE still continue to be causes of high mortality and morbidity rates in cardiac surgery.


Arvay A, Lengyel M. 1988. Incidence and risk factors of prosthetic valve endocarditis. Eur J Cardiothorac Surg 2:340-6.nBalasubramanian SK, Behranwala A, Devbhandari M, et al. 2005. Predictors of mortality in early surgical intervention for active native valve endocarditis and significance of antimicrobial therapy: a single-center experience. J Heart Valve Dis 14:15-22.nBonow RO, Carabello BA, Chatterjee K, et al. 2006. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. J Am Coll Cardiol 48:el-148.nDiSalvo G, Habib G, Pergola V, et al. 2001. Echocardiography predicts embolic events in infective endocarditis. J Am Coll Cardiol 37:1069-76.nDoukas G, Oc M, Alexiou C, Sosnowski AW, et al. 2006. Mitral valve repair for active culture positive infective endocarditis. Heart 92:361-3.nDurack DT, Lukes AS, Bright DK. 1994. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. Am J Med 96:200-9.nHorstkotte D, Follath F, Gutschik E, et al. 2004. Guidelines on prevention, diagnosis and treatment of infective endocarditis executive summary: the Task Force on Infective Endocarditis of the European Society of Cardiology. Eur Heart J 25:267-76.nHorstkotte D, Piper C, Niehues R, et al. 1995. Late prosthetic valve endocarditis. Eur Heart J 16:39-47.nHumphrey PR, Harrison MJ. 1985. How often can an embolic stroke be diagnosed clinically? A clinicopathological correlation. Postgrad Med J 61:1039-42.nKorzeniowski OM, Kaye D. 1998. Endocarditis. In: Gorbach SL, Bartlett JG, Blacklow NR, eds. Infectious diseases. 2nd ed. Philadelphia, Pa: W.B. Saunders. p 663-71.nRamsdale DR, Turner-Stokes L, Advisory Group of the British Cardiac Society Clinical Practice Committee, RCP Clinical Effectiveness and Evaluation Unit. 2004. Prophylaxis and treatment of infective endocarditis in adults: a concise guide. Clin Med 4:545-50.nRutledge R, Kim J, Applebaum RE. 1998. Actuarial analysis of the risk of prosthetic valve endocarditis in 1,598 patients with mechanical and bioprosthetic valves. Arch Surg 120:469-72.nSaleh A, Dawkins K, Monro J. 2004. Surgical treatment of infective endocarditis. Acta Cardiol 59:658-62.nSteckelberg JM, Murphy JG, Ballard D, et al. 1991. Emboli in infective endocarditis: the prognostic value of echocardiography. Ann Intern Med 114:635-40.nVlessis AA, Hovaguimian H, Jaggers J, et al. 1996. Infective endocarditis: ten-year review of medical and surgical therapy. Ann Thorac Surg 61:1217-22.nWeinstein L. 1986. Life threatening complications of infective endocarditis and their management. Arch Intern Med 146:953-7.n



How to Cite

Burma, O., Atik, C., Celkan, M. A., Üstünsoy, H., & Kazaz, H. (2008). Retrospective Analysis of Surgically Treated Infective Endocarditis Cases. The Heart Surgery Forum, 11(2), E90-E93.