Coronary Endarterectomy with Beating Heart in Patients with Diffuse Atheromatous Coronary Artery Disease and Poor Ventricular Function: Early and Midterm Results
DOI:
https://doi.org/10.1532/HSF98.20041165Abstract
Background: In this study, we retrospectively reviewed our experience with off-pump coronary artery bypass grafting and coronary artery endarterectomy in patients with severely reduced left ventricular function and diffuse atheromatous coronary artery disease to evaluate the early and midterm results.
Methods: Between July 1998 and March 2004, 42 patients underwent off-pump myocardial revascularization with coronary artery endarterectomy. The mean age ( ± SD) for the 28 male and 14 female patients was 59 ± 10.2 years. Twenty-seven patients (64.2%) had experienced a previous myocardial infarction, and 11 (26.2%) had undergone an operation on an emergency basis. All patients had an ejection fraction of less than 30%. The left anterior descending coronary artery was the most endarterectomized vessel (75% of patients).
Results: There were 5 early deaths (11%). Twenty-five (67.6%) of the surviving patients were symptom free, and 8 were in Canadian Cardiovascular Society classes II to IV. The ejection fraction improved after the operation in the 30 patients (71.42%) who underwent echocardiographic control and coronary angiography. The 28.4-month patency rate of the endarterectomized coronary arteries was 89%. The patency rates were 93.3% for the left internal thoracic artery-left anterior descending coronary artery and 88.8% for the right coronary artery.
Conclusion: The results of this study show increased operative mortality and morbidity in patients requiring coronary artery endarterectomy. However, the early results and particularly the midterm survival rates, clinical status, and continued graft patency justify off-pump coronary artery endarterectomy in patients with severely depressed left ventricular function and diffuse coronary artery disease. Many of these patients have disease that would otherwise be inoperable.
References
Christakis GT, Ivanov J, Weisel RD, Birnbaum PL, David TE, Salerno TA. 1989. The changing pattern of coronary bypass surgery. Circulation 80:I-151-61.nChristakis GT, Weisel RD, Fremes SE, et al. 1992. Coronary artery bypass grafting in patients with poor ventricular function: Cardiovascular Surgeons of the University of Toronto. J Thorac Cardiovasc Surg 103: 1083-92.nCosgrove DM, Loop FD, Lytle BW, et al. 1984. Primary myocardial revascularization: trends in surgical mortality. J Thorac Cardiovasc Surg 88:673-84.nCukingnan RA, Carey JS, Witting JH, Brown BG. 1980. Influence of complete coronary revascularization on relief of angina. J Thorac Cadiovasc Surg 79:188-93.nDjalilian AR, Shumway SJ. 1995. Adjunctive coronary endarterecomy: improved safety in modern cardiac surgery. Ann Thorac Surg 60:1749-54.nEryilmaz S, Inan MB, Eren NT, Yazicioglu L, Corapcioglu T, Akalin H. 2003. Coronary endarterectomy with off-pump coronary artery bypass surgery. Ann Thorac Surg 75:865-69.nEvans RW, Maier AM. 1986. Outcome of patients referred for cardiac transplantation. J Am Coll Cardiol 8:1312-7.nBell MR, Gersh BJ, Schaff HV, et al. 1992. Effect of completeness or revascularization on long-term outcome of patients with three-vessel disease undergoing coronary artery bypass surgery: a report from the Coronary Artery Surgery Study (CASS) Registry. Circulation 86: 446-57.nBrenowitz JB, Kayser KL, Johnson ND. 1988. Results of coronary endarterectomy and reconstruction. J Thorac Cardiovasc Surg 95:1-10.n[CASS]CASS Principal Investigators and their associates. 1983. Coronary artery surgical study (CASS): a randomized trial of coronary artery bypass surgery: survival data. Circulation 68:939-50.nGill IS, Beanlands DS, Boyd WD, Finlay S, Keon WJ. 1998. Left anterior descending endarterectomy and internal thoracic artery bypass for diffuse coronary disease. Ann Thorac Surg 65:659-62.nJones EL, Craver JM, Guyton RA, Bones DK, Hatcher CR Jr, Riechwald N. 1983. Importance of complete revascularization in performance of the coronary bypass operation. Am J Cardiol 51:7-12.nKeon WJ, Master RG, Koshal A, Hendry P, Farrell EM. 1988. Coronary endarterectomy: an adjunct to coronary artery bypass grafting. Surg Clin North Am 68:669-78.nLawrie GM, Morris GC Jr, Silvers A. 1982. The influence of residual disease after coronary bypass on the 5-year survival rate of 1274 men with coronary artery disease. Circulation 66:717-23.nLivesay JJ, Cooley DA, Hallman GL. 1986. Early and late results of coronary endarterectomy: analysis of 3,369 patients. J Thorac Cardiovasc Surg 92:649-60.nMcCormick JR, Schick EC Jr, McCabe CH, Kronmal RA, Ryan TJ. 1985. Determinants of operative mortality and long-term survival in patients with unstable angina: the CASS experience. J Thorac Cardiovasc Surg 89:683-8.nMilano CA, White WD, Smith RL, et al. 1993. Coronary artery bypass in patients with severely depressed ventricular function. Ann Thorac Surg 56:487-93.nMinale C, Nikol J, Zander M, Uebis R, Effert S, Messmer BJ. 1989. Controversial aspects of coronary endarterectomy. Ann Thorac Surg 48:235-41.nQuigley RL. 2004. Synergy of old and new technology results in successful revascularization of the anterior myocardium with relief of angina in the absence of suitable targets. Heart Surg Forum 7:E343-8.nSchaff HV, Gersh BJ, Pluth JR, et al. 1983. Survival and functional status after coronary artery bypass grafting: results 10 to 12 years after surgery in 500 patients. Circulation 68:II-200-4.nWright JG, Pifarre R, Sullivan HS. 1987. Multivariate discriminant analysis of risk factors for operative mortality following isolated coronary artery bypass graft: Loyola University Medical Center experience, 19701984. Chest 91:394-9.n