Anticoagulation in Pregnant Women with a Bileaflet Mechanical Cardiac Valve Replacement


  • Kyung-Hwan Kim
  • Dong Seop Jeong
  • Hyuk Ahn



Background. We investigated the risk and outcome of anticoagulation in pregnant women who had a mechanical valve.

Materials and Methods. This retrospective study was undertaken for 41 pregnancies (27 women, 33.1 ± 4.7 years old) from January 1990 to December 2005. Patients were divided into 3 groups: group I (n = 5) took warfarin throughout the pregnancy, group II (n = 18) took heparin throughout the pregnancy, and group III (n = 18) took heparin in the 1st trimester and warfarin from a gestational age of 12 to 20 weeks.

Results. Twenty-three pregnancies (56.1%) resulted in live births, 11 (26.8%) in stillbirths, and 8 (19.5%) in spontaneous abortions (SA). In group I, there were 2 live births (40.0%), 2 stillbirths (40.0%), and 1 SA (20.0%); in group II, there were 10 live births (55.6%), 1 stillbirth (5.6%), and 7 SA (38.9%); and in group III, there were 10 live births (55.6%), 8 stillbirths (44.4%), and no SA. No significant difference was observed between the 3 groups in terms of successful delivery rates (P = .826).

Conclusion. The probability of successful delivery was low. No single reliable anticoagulation protocol in pregnant patients with mechanical valves emerged from the collated data.


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How to Cite

Kim, K.-H., Jeong, D. S., & Ahn, H. (2007). Anticoagulation in Pregnant Women with a Bileaflet Mechanical Cardiac Valve Replacement. The Heart Surgery Forum, 10(4), E267-E270.