Long-Term Outcomes in Patients Undergoing Thoracic Endovascular Aortic Repair. Single Center Experience

Authors

  • Aleksander Dokollari Cardiac Surgery Department, St. Boniface Hospital, University of Manitoba, Winnipeg, MB R3T 2N2, Canada https://orcid.org/0000-0001-8032-1741
  • Serge Sicouri Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA; Department of Cardiac Surgery, Lankenau Medical Center, Main Line Health, Wynnewood, PA 19096, USA
  • Roberto Rodriguez Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA
  • Robert Meisner Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA
  • Henry Hirsch Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA
  • Vincent DiGiovanni Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA
  • Alexander Uribe Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA
  • Mohammad El-Diasty Cardiac Surgery Department, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, USA
  • Beatrice Bacchi Cardiac Surgery Unit, Clinical and Experimental Department, University of Florence, 50121 Florence, Italy
  • Francesco Cabrucci Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA; Cardiac Surgery Unit, Clinical and Experimental Department, University of Florence, 50121 Florence, Italy
  • Ali Fatehi Hassanabad Section of Cardiac Surgery, Division of Cardiac Sciences, Libin Cardiovascular Institute, University of Calgary, Calgary, AB T2N 1N4, Canada
  • Sandro Gelsomino Cardiothoracic Department, Maastricht University Hospital, 6229 HX Maastricht, The Netherlands
  • Giulia Elena Mandoli Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy
  • Matteo Cameli Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy
  • Massimo Bonacchi Cardiac Surgery Unit, Clinical and Experimental Department, University of Florence, 50121 Florence, Italy
  • Basel Ramlawi Department of Cardiac Surgery, Lankenau Medical Center, Main Line Health, Wynnewood, PA 19096, USA

DOI:

https://doi.org/10.59958/hsf.8099

Keywords:

thoracic endovascular aortic repair (TEVAR), long-term outcome, major adverse cardiovascular and cerebrovascular events (MACCE)

Abstract

Background: To analyze long-term outcomes in patients undergoing thoracic endovascular aortic repair (TEVAR). Methods: All consecutive 97 patients undergoing TEVAR between September 2014 and September 2022 were included in the study. The primary outcome was the long-term incidence of overall death and major adverse cardiovascular and cerebrovascular events (MACCE). Results: Mean age was 70.4 years, and 22 (23.2%) had cerebrovascular disease (CBVD). 49 (51.6%) patients had prior cardiac surgery intervention and 8 (8.5%) had prior aortic valve replacement. Twenty-eight patients (28.8%) presented with aortic dissection, 60 (61.8%) had aortic aneurysm, 4 (4.1%) had intramural hematoma, and 5 (5.1%) had other presentations. An emergent procedure was performed in 6 (6.2%) patients, an urgent procedure in 37 (38.1%) patients and 54 (55.7%) patients had an elective procedure. Intraoperatively, 78.3% had percutaneous TEVAR, 5.1% had ministernotomy TEVAR, while 10.3% had concomitant full sternotomy TEVAR repair. Hospital mortality occurred in 7 patients (7.2%). At 8-year follow-up, 76% were alive, 25.8% had MACCE, 21.6% were diagnosed with endoleaks (13 patients type II and 2 patients type 1) and 10.3% underwent repeat intervention. Conclusions: This single-center study found that patients undergoing TEVAR had good short- and long-term survival and MACCE. Despite almost half of the patients undergoing an urgent/emergent procedure, the clinical outcomes were favorable for TEVAR.

References

Weissler EH, Osazuwa-Peters OL, Greiner MA, Hardy NC, Kougias P, O'Brien SM, et al. Initial Thoracic Endovascular Aortic Repair vs Medical Therapy for Acute Uncomplicated Type B Aortic Dissection. JAMA Cardiology. 2023; 8: 44–53. https://doi.org/10.1001/jamacardio.2022.4187.

Patel R, Sweeting MJ, Powell JT, Greenhalgh RM, EVAR trial investigators. Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial. Lancet (London, England). 2016; 388: 2366–2374. https://doi.org/10.1016/S0140-6736(16)31135-7.

Anaya-Ayala JE, Cheema ZF, Davies MG, Bismuth J, Ramlawi B, Lumsden AB, et al. Hybrid thoracic endovascular aortic repair via right anterior minithoracotomy. The Journal of Thoracic and Cardiovascular Surgery. 2011; 142: 314–318. https://doi.org/10.1016/j.jtcvs.2010.10.032.

Ramlawi B, Reardon MJ. Aortic arch debranching: advanced and hybrid techniques. Methodist DeBakey Cardiovascular Journal. 2011; 7: 43–47. https://doi.org/10.14797/mdcj-7-3-43.

Leurs LJ, Bell R, Degrieck Y, Thomas S, Hobo R, Lundbom J, et al. Endovascular treatment of thoracic aortic diseases: combined experience from the EUROSTAR and United Kingdom Thoracic Endograft registries. Journal of Vascular Surgery. 2004; 40: 670–679; discussion 679–680. https://doi.org/10.1016/j.jvs.2004.07.008.

Bonacchi M, Cabrucci F, Bacchi B, Haranal M, Gelsomino S, Ramlawi B, et al. Editorial: Novel insights into aortic arch repair. Frontiers in Cardiovascular Medicine. 2022; 9: 1087952. https://doi.org/10.3389/fcvm.2022.1087952.

Dokollari A, Bisleri G. Commentary: Watchful waiting during visceral malperfusion in DeBakey type I aortic dissection: A possible paradigm shift? JTCVS Techniques. 2020; 4: 81–82. https://doi.org/10.1016/j.xjtc.2020.08.054.

Tong MZ, Eagleton MJ, Roselli EE, Blackstone EH, Xiang F, Ibrahim M, et al. Outcomes of Open Versus Endovascular Repair of Descending Thoracic and Thoracoabdominal Aortic Aneurysms. The Annals of Thoracic Surgery. 2022; 113: 1144–1152. https://doi.org/10.1016/j.athoracsur.2021.04.100.

Coselli JS, Rosu C, Amarasekara HS, Green SY, Zhang Q, Price MD, et al. Reoperative surgery on the thoracoabdominal aorta. The Journal of Thoracic and Cardiovascular Surgery. 2018; 155: 474–485.e1. https://doi.org/10.1016/j.jtcvs.2017.08.024.

Braconi L, Cabrucci F, Bacchi B, Bonacchi M. A threatening meteor for cardiac surgeons: anomalous left main coronary origin in type A aortic dissection. European Journal of Cardio-thoracic Surgery. 2022; 62: ezac411. https://doi.org/10.1093/ejcts/ezac411.

Isselbacher EM, Preventza O, Hamilton Black J, 3rd, Augoustides JG, Beck AW, Bolen MA, et al. 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2022; 146: e334–e482. https://doi.org/10.1161/CIR.0000000000001106.

Matsumura JS, Cambria RP, Dake MD, Moore RD, Svensson LG, Snyder S, et al. International controlled clinical trial of thoracic endovascular aneurysm repair with the Zenith TX2 endovascular graft: 1-year results. Journal of Vascular Surgery. 2008; 47: 247–257; discussion 257. https://doi.org/10.1016/j.jvs.2007.10.032.

Lee WA, Daniels MJ, Beaver TM, Klodell CT, Raghinaru DE, Hess PJ, Jr. Late outcomes of a single-center experience of 400 consecutive thoracic endovascular aortic repairs. Circulation. 2011; 123: 2938–2945. https://doi.org/10.1161/CIRCULATIONAHA.110.965756.

Rodriguez JA, Olsen DM, Shtutman A, Lucas LA, Wheatley G, Alpern J, et al. Application of endograft to treat thoracic aortic pathologies: a single center experience. Journal of Vascular Surgery. 2007; 46: 413–420. https://doi.org/10.1016/j.jvs.2007.05.042.

Riambau V, Zipfel B, Coppi G, Czerny M, Tealdi DG, Ferro C, et al. Final operative and midterm results of the European experience in the RELAY Endovascular Registry for Thoracic Disease (RESTORE) study. Journal of Vascular Surgery. 2011; 53: 565–573. https://doi.org/10.1016/j.jvs.2010.09.050.

Fillinger MF, Greenberg RK, McKinsey JF, Chaikof EL, Society for Vascular Surgery Ad Hoc Committee on TEVAR Reporting Standards. Reporting standards for thoracic endovascular aortic repair (TEVAR). Journal of Vascular Surgery. 2010; 52: 1022–1033, 1033.e15. https://doi.org/10.1016/j.jvs.2010.07.008.

Alric P, Canaud L, Branchereau P, Marty-Anne C. Traitement endovasculaire des anevrysmes de l’aorte thoracique descendante. EMC Techniques Chirurgicales – Chirurgie Vasculaire. 2012; 7: 1–20. (In French)

Dokollari A, Cameli M, Wang L, Bisleri G. Aortic intimo-intimal intussusception in Stanford type A acute aortic dissection. European Heart Journal. 2021; 42: 3410. https://doi.org/10.1093/eurheartj/ehaa886.

Bonacchi M, Dokollari A, Parise O, Sani G, Prifti E, Bisleri G, et al. Ministernotomy compared with right anterior minithoracotomy for aortic valve surgery. The Journal of Thoracic and Cardiovascular Surgery. 2023; 165: 1022–1032.e2. https://doi.org/10.1016/j.jtcvs.2021.03.125.

Dokollari A, Cameli M, Mandoli GE, Kalra DKS, Poston R, Coku L, et al. Early and Midterm Clinical Outcomes of Transcatheter Valve-in-Valve Implantation Versus Redo Surgical Aortic Valve Replacement for Aortic Bioprosthetic Valve Degeneration: Two Faces of the Same Medal. Journal of Cardiothoracic and Vascular Anesthesia. 2021; 35: 3223–3231. https://doi.org/10.1053/j.jvca.2021.05.029.

Tsilimparis N, Stana J, Konstantinou N, Chen M, Zhou Q, Kölbel T. Identifying risk factors for early neurological outcomes following thoracic endovascular aortic repair using the SUMMIT database. European Journal of Cardio-thoracic Surgery. 2022; 62: ezab476. https://doi.org/10.1093/ejcts/ezab476.

Zha Z, Pan Y, Zheng Z, Wei X. Prognosis and Risk Factors of Stroke After Thoracic Endovascular Aortic Repair for Stanford Type B Aortic Dissection. Frontiers in Cardiovascular Medicine. 2022; 8: 787038. https://doi.org/10.3389/fcvm.2021.787038.

Chung J, Corriere MA, Veeraswamy RK, Kasirajan K, Milner R, Dodson TF, et al. Risk factors for late mortality after endovascular repair of the thoracic aorta. Journal of Vascular Surgery. 2010; 52: 549–554; discussion 555. https://doi.org/10.1016/j.jvs.2010.04.059.

Morales JP, Greenberg RK, Lu Q, Cury M, Hernandez AV, Mohabbat W, et al. Endoleaks following endovascular repair of thoracic aortic aneurysm: etiology and outcomes. Journal of Endovascular Therapy. 2008; 15: 631–638. https://doi.org/10.1583/08-2551.1.

Bischoff MS, Geisbüsch P, Kotelis D, Müller-Eschner M, Hyhlik-Dürr A, Böckler D. Clinical significance of type II endoleaks after thoracic endovascular aortic repair. Journal of Vascular Surgery. 2013; 58: 643–650. https://doi.org/10.1016/j.jvs.2013.03.026.

Kanaoka Y, Ohki T, Maeda K, Baba T. Analysis of Risk Factors for Early Type I Endoleaks After Thoracic Endovascular Aneurysm Repair. Journal of Endovascular Therapy. 2017; 24: 89–96. https://doi.org/10.1177/1526602816673326.

Bonacchi M, Prifti E, Giunti G, Frati G, Sani G. Does ministernotomy improve postoperative outcome in aortic valve operation? A prospective randomized study. The Annals of Thoracic Surgery. 2002; 73: 460–465; discussion 465–466. https://doi.org/10.1016/s0003-4975(01)03402-6.

Prifti E, Bonacchi M, Frati G, Proietti P, Giunti G, Babatasi G, et al. Early and long-term outcome in patients undergoing aortic root replacement with composite graft according to the Bentall's technique. European Journal of Cardio-thoracic Surgery. 2002; 21: 15–21. https://doi.org/10.1016/s1010-7940(01)01037-5.

de Jong MM, Lorusso R, Al Awami F, Matteuci F, Parise O, Lozekoot P, et al. Vascular complications following intra-aortic balloon pump implantation: an updated review. Perfusion. 2018; 33: 96–104. https://doi.org/10.1177/0267659117727825.

Seike Y, Matsuda H, Shimizu H, Ishimaru S, Hoshina K, Michihata N, et al. Nationwide Analysis of Persistent Type II Endoleak and Late Outcomes of Endovascular Abdominal Aortic Aneurysm Repair in Japan: A Propensity-Matched Analysis. Circulation. 2022; 145: 1056–1066. https://doi.org/10.1161/CIRCULATIONAHA.121.056581.

Published

2025-01-21

How to Cite

Dokollari, A., Sicouri, S., Rodriguez, R. ., Meisner, R., Hirsch, H., DiGiovanni, V., Uribe, A., El-Diasty, M., Bacchi, B., Cabrucci, F., Hassanabad, A. F. ., Gelsomino, S., Mandoli, G. E., Cameli, M., Bonacchi, M., & Ramlawi, B. (2025). Long-Term Outcomes in Patients Undergoing Thoracic Endovascular Aortic Repair. Single Center Experience. The Heart Surgery Forum, 28(1), E086–E095. https://doi.org/10.59958/hsf.8099

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