Optimizing Blood Loss Management and Transfusion Strategies in Cardiac Surgery

Xintong  Yu; Ting Yin; Shiyong  Mao; Weiding Tang

doi:10.59958/hsf.7969

Authors

Xintong Yu Department of Surgery, Affiliated Hospital of Jiangsu University, 212000 Zhenjiang, Jiangsu, China https://orcid.org/0009-0009-7001-0005
Ting Yin Department of Operating Room, Affiliated Hospital of Jiangsu University, 212000 Zhenjiang, Jiangsu, China https://orcid.org/0009-0007-0878-3862
Shiyong Mao Department of Surgery, Affiliated Hospital of Jiangsu University, 212000 Zhenjiang, Jiangsu, China https://orcid.org/0009-0006-7754-4550
Weiding Tang Department of Surgery, Affiliated Hospital of Jiangsu University, 212000 Zhenjiang, Jiangsu, China https://orcid.org/0009-0002-6447-3475

DOI:

https://doi.org/10.59958/hsf.7969

Keywords:

cardiac surgery, blood conservation, antifibrinolytic agents, surgical outcomes

Abstract

Background: An increase in healthcare costs is the result of the significant hazards to patients associated with excessive blood loss during cardiac surgery and the subsequent need for transfusions. The implementation of effective blood conservation strategies may alleviate these issues. Objectives: This study aimed to assess the correlation between the utilization of anti-fibrinolytic agents and the outcomes of blood loss and transfusion requirements during cardiac interventions, with a particular emphasis on integrated blood conservation strategies. Methods: We conducted a cross-sectional observational study, enrolling 242 patients who underwent elective cardiac surgery, which included valve replacements and coronary artery bypass grafting. The study contrasted the outcomes of patients who received standard surgical care and those who were administered tranexamic acid or aminocaproic acid as part of blood conservation efforts. Results: The results showed a significant reduction in the mean intraoperative blood loss (212.7 vs. 310.4 mL, p < 0.05) and transfusion volume (330.2 vs. 490.1 mL, p < 0.05) in patients who received anti-fibrinolytic agents. Furthermore, these patients experienced shorter hospital stays and lower rates of postoperative complications, such as infections and thrombotic events, in comparison to those who received standard care. Conclusion: The implementation of anti-fibrinolytic agents and other targeted blood conservation strategies may be advantageous in minimizing blood loss and transfusion requirements, which could potentially result in enhanced recovery metrics in cardiac surgery. In order to improve patient outcomes, these strategies should be incorporated into standard surgical protocols.

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Optimizing Blood Loss Management and Transfusion Strategies in Cardiac Surgery

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