Single-Center Retrospective Analysis of Acute Type A Aortic Dissection Outcome and Reoperation Focusing on Extended Versus Limited Initial Repair

Authors

  • Mohamed Elbayomi, MB, BCh Department of Cardiac Surgery, Friedrich-Alexander-University, Erlangen, Germany
  • Michael Weyand, MD Department of Cardiac Surgery, Friedrich-Alexander-University, Erlangen, Germany
  • Presheet Pathare, MD Department of Cardiac Surgery, Friedrich-Alexander-University, Erlangen, Germany
  • Ehab Nooh, MD Department of Cardiac Surgery, Friedrich-Alexander-University, Erlangen, Germany
  • Frank Harig, MD Department of Cardiac Surgery, Friedrich-Alexander-University, Erlangen, Germany

DOI:

https://doi.org/10.1532/hsf.5345

Keywords:

Acute aortic dissection, reoperation, cardiopulmonary bypass

Abstract

Background: The optimal management strategy for acute aortic type A dissection remains controversial. Whether a limited primary (index) repair would increase the need for late aortic reintervention is still an open debate.

Methods: A total of 393 consecutive adult patients with acute type A aortic dissection who underwent cardiac surgery were analyzed. Our research hypothesis was whether limited aortic index repair (i.e., isolated aorta ascending replacement without an open distal anastomosis with and without a concomitant aortic valve replacement, including hemiarch replacement procedure) is associated with a higher incidence of late aortic reoperation compared with extended repair (i.e., any other surgical procedure that goes beyond that limited approach).

Results: Type of the initial repair had no statically significant relationship with in-hospital mortality with a P-value of 0.12, however in multivariable analysis, cross-clamp time had a statistically significant relation with mortality (P = 0.4). From the patients who survived until discharge (N = 311), 40 patients needed a reoperation on the aorta; the mean interval until reoperation was 4.5 years. The relationship between the type of the initial repair and the need for reoperation didn’t reach a statically significant value (P = 0.9). In-hospitable mortality after the second operation was 10% (N = 4).

Conclusion: We reached two conclusions. 1) An extended prophylactic repair in the initial operation of an acute type A aortic dissection might not lead to a lower incidence of reoperations on the aorta and could increase in-hospital mortality by increasing cross-clamp time, and 2) Reoperation on the aorta could be done safely with acceptable mortality outcomes.

References

Al-Sarraf N, Thalib L, Hughes A, et al. 2011. Cross-clamp time is an independent predictor of mortality and morbidity in low- and high-risk cardiac patients. Int J Surg. 9(1):104-109.

Bonser RS, Ranasinghe AM, Loubani M, et al. 2011. Evidence, Lack of Evidence, Controversy, and Debate in the Provision and Performance of the Surgery of Acute Type A Aortic Dissection. J Am Coll Cardiol. 2011;58(24):2455-2474.

De Bakey ME, Cooley DA, Creech O. 1955. Surgical Considerations of Dissecting Aneurysm of the Aorta. Ann Surg. 142(4):586-610.

Doenst T, Borger MA, Weisel RD, Yau TM, Maganti M, Rao V. 2008. Relation between aortic cross-clamp time and mortality — not as straightforward as expected. Eur J Cardiothorac Surg. 33(4):660-665.

Eusanio MD, Berretta P, Cefarelli M, et al. 2015. Total Arch Replacement Versus More Conservative Management in Type A Acute Aortic Dissection. Ann Thorac Surg. 100(1):88-94.

Giebels C, Aicher D, Kunihara T, Rodionycheva S, Schmied W, Schäfers HJ. 2013. Causes and management of aortic valve regurgitation after aortic valve reimplantation. J Thorac Cardiovasc Surg. 145(3):774-780.

Hagan PG, Nienaber CA, Isselbacher EM, et al. 2000. The International Registry of Acute Aortic Dissection (IRAD)New Insights Into an Old Disease. JAMA. 283(7):897-903.

Li B, Ma WG, Liu YM, Sun LZ. 2015. Is extended arch replacement justified for acute type A aortic dissection? Interact Cardiovasc Thorac Surg. 20(1):120-126.

Moorjani N. 2014. Cardiac Surgery: Recent Advances and Techniques. CRC Press.

Nicholls F. 1761. Observations Concerning the Body of His Late Majesty, October 26, 1760, by Frank Nicholls, M. D. F. R. S. Physician to His Late Majesty. Philosophical Transactions (1683-1775).

Parikh N, Trimarchi S, Gleason TG, et al. 2017. Changes in operative strategy for patients enrolled in the International Registry of Acute Aortic Dissection interventional cohort program. J Thorac Cardiovasc Surg. 153(4):S74-S79.

Pathare P, Elbayomi M, Tandler R, Weyand M, Harig F. Successive surgical repair of a progressive aortic dissection in a case of Loeys–Dietz Syndrome. J Card Surg.

Roques F, Nashef SAM, Michel P, et al. 1999. Risk factors and outcome in European cardiac surgery: analysis of the EuroSCORE multinational database of 19030 patients. Eur J Cardiothorac Surg. 15(6):816-823.

Rylski B, Beyersdorf F, Kari FA, Schlosser J, Blanke P, Siepe M. 2014. Acute type A aortic dissection extending beyond ascending aorta: Limited or extensive distal repair. J Thorac Cardiovasc Surg. 148(3):949-954.

Salsano A, Giacobbe DR, Sportelli E, et al. 2018. Aortic cross-clamp time and cardiopulmonary bypass time: prognostic implications in patients operated on for infective endocarditis. Interact Cardiovasc Thorac Surg. 27(3):328-335.

Stassano P, Di Tommaso L, Monaco M, et al. 2009. Aortic Valve Replacement: A Prospective Randomized Evaluation of Mechanical Versus Biological Valves in Patients Ages 55 to 70 Years. J Am Coll Cardiol. 54(20):1862-1868.

Zheng J, Xu SD, Zhang YC, et al. 2019. Association between cardiopulmonary bypass time and 90-day post-operative mortality in patients undergoing arch replacement with the frozen elephant trunk: a retrospective cohort study. Chin Med J (Engl). 132(19):2325-2332.

Published

2023-03-03

How to Cite

Elbayomi, M., Weyand, M., Pathare, P., Nooh, E., & Harig, F. (2023). Single-Center Retrospective Analysis of Acute Type A Aortic Dissection Outcome and Reoperation Focusing on Extended Versus Limited Initial Repair. The Heart Surgery Forum, 26(2), E164-E169. https://doi.org/10.1532/hsf.5345

Issue

Section

Article