A Rare Case of Primary Malignant Pericardial Mesothelioma Diagnosed with Pericardiotomy

Primary Malignant Pericardial Mesothelioma

Authors

  • Fenfen Cui, M.M Department of Cardiovascular Surgery, The First Hospital of Lanzhou University, Lanzhou, China
  • Yuan Hu, M.M Department of Cardiovascular Surgery, The First Hospital of Lanzhou University, Lanzhou, China
  • Yuanmin Li, M.M Department of Cardiovascular Surgery, The First Hospital of Lanzhou University, Lanzhou, China

DOI:

https://doi.org/10.1532/hsf.5047

Keywords:

pericardial mesothelioma, tumor, pericardiotomy, pericardium

Abstract

Primary malignant pericardial mesothelioma (PMPM) is an extremely rare and lethal cardiac tumor. This article presents a 62-year-old man with recurrent pericardial fluid. The patient’s clinical symptoms and imaging features were nonspecific. Initial diagnosis was constrictive pericarditis. After admission, the patient’s symptoms worsened, and echocardiography indicated increased pericardial effusion. To diagnose and improve the patient’s symptoms, pericardiotomy was performed; however, the procedure was unsuccessful because the pericardium was densely adherent to the myocardium. Histopathological examination, including immunohistochemical staining of the pericardial specimen revealed malignant mesothelioma. We recommended adjuvant therapy for the patient with cis-platinum and pemetrexed; however, the patient and his family refused treatment. The patient was discharged 11 days after surgery. The patient survived for more than 15 months with surgical treatment. In this report, the patient’s symptoms improved, and the patient survived beyond the median survival after surgical treatment.  

Conclusion: The definitive diagnosis of PMPM mostly has been obtained from specimens obtained by surgery. Surgery is an effective treatment method because it prevents cardiac tamponade and can improve symptoms or prognosis, but complete resection is impossible.

References

Apicella G, Boulemden A, Citarella A, et al. 2020. Surgical treatment of a primary malignant pericardial mesothelioma: case report. Acta chirurgica Belgica. (2): 1-8.

Kong LY, Wang JR, Sun LL, et al. 2017. Clinical, Imaging, Pathological and Prognostic Analysis of Primary Malignant Pericardial Mesothelioma in Inland China: A 35-year Review. Chinese Circulation Journal. 32(010):1005-1009.

Massicotte G, Bernier M, Piché ME, et al. 2019. Case Report of Aggressive Primary Pericardial Mesothelioma Presenting as a Constrictive Pericarditis.Circulation Cardiovascular Imaging. 12(3):e008621.

Matsuyama S, Imazuru T, Uchiyama M, Ota H, et al. 2020. Primary Malignant Pericardial Mesothelioma Presenting with Cardiac Tamponade. International Journal of Surgery Case Reports. 73.

Mcgehee E, Gerber DE, Reisch J, et al. 2018. Treatment and Outcomes of Primary Pericardial Mesothelioma:A Contemporary Review of 103 Published Cases.Clinical Lung Cancer. (3):e152-e157.

Published

2022-12-19

How to Cite

cui, fenfen, hu, yuan, & li, yuanmin. (2022). A Rare Case of Primary Malignant Pericardial Mesothelioma Diagnosed with Pericardiotomy: Primary Malignant Pericardial Mesothelioma. The Heart Surgery Forum, 25(6), E840-E842. https://doi.org/10.1532/hsf.5047

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Article