Rapidly Progressive Right Atrial Angiosarcoma with Atrial Perforation
DOI:
https://doi.org/10.1532/hsf.4803Keywords:
cardiac tumor, cardiac sarcoma, angiosarcomaAbstract
Cardiac angiosarcomas are highly aggressive, extremely rare malignancies with a poor prognosis. We report the case of a 39-year-old woman presenting with a right atrial angiosarcoma with perforation of the right atrium. There is almost always a diagnostic lag for cardiac angiosarcoma, leading to a poor prognosis. Cardiovascular sarcoma is one of the most invasive malignant tumors. Radical resection surgery as the core of comprehensive treatment presently is the best treatment plan.
References
Bhattacharyya S, Khattar R, Senior R. 2013. Characterisation of intra-cardiac masses by myocardial contrast echocardiography. Int J Cardiol. 163:E11-3.
Burke A, Tavora F. 2016. The 2015 WHO classification of tumors of the heart and pericardium. J Thorac Oncol. 11:441-52.
Cao J, Wang J, He C, Fang M. 2019. Angiosarcoma: a review of diagnosis and current treatment. Am J Cancer Res. 9:2303-13.
Chen YA, Li Y, Lee JC, Chen JW. 2021. Staged surgery for advanced cardiac intimal sarcoma involving the right atrium and the inferior vena cava. J Card Surg. 36:3973-5.
Ekmektzoglou KA, Samelis GF, Xanthos T. 2008. Heart and tumors: location, metastasis, clinical manifestations, diagnostic approaches and therapeutic considerations. J Cardiovasc Med (Hagerstown). 9:769-77.
Florou V, Wilky BA. 2021. Current Management of Angiosarcoma: Recent Advances and Lessons From the Past. Curr Treat Options Oncol. 22(7):61.
Gaballah AH, Jensen CT, Palmquist S, Pickhardt PJ, Duran A, Broering G, et al. 2017. Angiosarcoma: clinical and imaging features from head to toe. Br J Radiol. 90.
Hamidi M, Moody JS, Weigel TL, Kozak KR. 2010. Primary cardiac sarcoma. Ann Thorac Surg. 90:176-81.
Hata M. 2018. Radiation therapy for angiosarcoma of the scalp: total scalp irradiation and local irradiation. Anticancer Res. 38:1247-53.
Kupsky DF, Newman DB, Kumar G, Maleszewski JJ, Edwards WD, Klarich KW. 2016. Echocardiographic features of cardiac angiosarcomas: the mayo clinic experience (1976-2013). Echocardiography. 33:186-92.
Mangla A, Gupta A, Mansur DB, et al. 2021. Right atrial cardiac angiosarcoma treated with concurrent proton beam therapy and paclitaxel: A novel approach to a rare disease. Thorac Cancer. 12(7):1131-1133.
Patel J, Sheppard MN. 2010. Pathological study of primary cardiac and pericardial tumours in a specialist UK Centre: surgical and autopsy series. Cardiovasc Pathol. 19:343-52.
Talbot SM, Taub RN, Keohan ML, Edwards N, Galantowicz ME, Schulman LL. 2002. Combined heart and lung transplantation for unresectable primary cardiac sarcoma. J Thorac Cardiovasc Surg. 124:1145-8.
Yadav U, Mangla A. 2020. Primary pericardial angiosarcoma: case report and review of treatment options. Ecancermedicalscience. 14:1056.
Young RJ, Brown NJ, Reed MW, Hughes D, Woll PJ. 2010. Angiosarcoma. Lancet Oncol. 11:983-91.
