Prognostic Value of Platelet-to-Platelet Distribution Width Ratio in Postoperative Patients with Type A Acute Aortic Dissection

PPR is a Prognostic Factor in Type A AAD

Authors

  • Yaman Wang, BA Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
  • Xiaohong Xia, BA Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
  • Qing Li, MD Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
  • Gaoxia Ge, MD Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
  • Jun Zhou, MD Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

DOI:

https://doi.org/10.1532/hsf.4605

Keywords:

acute, platelet, platelet distribution width, type A aortic dissection, in-hospital mortality

Abstract

Objective: Acute type A aortic dissection (AAD) is a serious life-threatening cardiovascular emergency with high in-hospital mortality without aggressive clinical treatment. The study intended to identify the relationship between platelet (PLT) to platelet distribution width (PDW) ratio (PPR) and in-hospital mortality in postoperative patients with type A AAD.

Methods: A total of 171 type A AAD patients were recruited in this retrospective study from January 2017 to December 2019. Receiver operating characteristics (ROC) were exploited to determine the best cut-off value of PPR, and then patients were sub-grouped into the low-PPR group and high-PPR group, according to the optimal value of PPR. Finally, univariate, and multivariate analyses were carried out to examine the prognostic value of PPR.

Results: The value of PPR was 9.76, and the mortality was statistically higher in the low-PPR group than in the high-PPR group (29.1% vs. 6.0%, P < 0.01). The area under the ROC curve (AUC) of PPR was 0.724 (95% CI, 0.633-0.815; P < 0.001) with a 56.4% sensitivity and 80.6% specificity. Multivariate analysis showed that serum PPR was an independent factor associated with in-hospital mortality (hazard ratio (HR): 1.151; 95% confidence interval (CI): 1.035 -1.297; P = 0.010).

Conclusion: Serum PPR can be used as an independent predictor of in-hospital mortality in postoperative patients with type A AAD.

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Published

2022-05-31

How to Cite

wang, yaman, xia, xiaohong, li, qing, ge, gaoxia, & zhou, jun. (2022). Prognostic Value of Platelet-to-Platelet Distribution Width Ratio in Postoperative Patients with Type A Acute Aortic Dissection: PPR is a Prognostic Factor in Type A AAD. The Heart Surgery Forum, 25(3), E413-E416. https://doi.org/10.1532/hsf.4605

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