The Impact of Serum Uric Acid on Postoperative Atrial Fibrillation in Coronary Artery Bypass Graft

Authors

  • Qian Zhang, MD Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, China
  • Yangyan Wei, MD Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, China
  • Jiwen Tang, BD Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, China
  • Siyang Huang, MD Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, China
  • Qing Chang, PhD Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao, China

DOI:

https://doi.org/10.1532/hsf.4603

Keywords:

Uric acid, Postoperative atrial fibrillation, coronary artery bypass

Abstract

Background: Postoperative atrial fibrillation (POAF) after cardiac surgery is a common complication. We aimed to investigate the impact of serum uric acid level (UA) on the POAF of patients undergoing coronary artery bypass grafting (CABG).

Methods: A retrospective cohort study of patients undergoing CABG at the Hospital between January 2019 and December 2019 was performed. Hyperuricemia (HUA) was defined as serum UA levels >420 µmol/l in men and>360 µmol/l in women. The included patients were divided into the HUA group (103) and the normal UA group (306) based on serum uric acid levels before surgery. POAF was defined as atrial fibrillation that occurred within 7 days of cardiac surgery. We use COX regression analysis and Kaplan-Meier curves (log-rank test) for statistical analysis.

Results: The incidence of HUA was 25.2% (103/409). The rate of POAF was 28.61%. Univariate COX regression analysis showed the risk of POAF occurrence. It was revealed that UA was an independent predictor of POAF (HR=1.493, 95% CI1.007-2.212, P = 0.046). Kaplan-Meier curves showed that high serum UA was associated with the occurrence of POAF (P = 0.034). Moreover, age (HR=1.05, 95%CI 1.024-1.076, P < 0.001), AD (HR=1.567, 95%CI .015-2.42, P = 0.043), and CCB (HR=0.647, 95%CI 0.424-0.988, P = 0.044) also were independent predictors of POAF.

Conclusions: Preoperative UA level was significantly associated with POAF. Higher serum UA was an independent risk factor for POAF.

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Published

2022-04-29

How to Cite

Zhang, Q., Wei, Y., Huang, S., Tang, J., & Chang, Q. (2022). The Impact of Serum Uric Acid on Postoperative Atrial Fibrillation in Coronary Artery Bypass Graft. The Heart Surgery Forum, 25(2), E320-E325. https://doi.org/10.1532/hsf.4603

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Articles