Early Outcomes of Emergency Surgery for Left-Sided Mechanical Valve Thrombosis
DOI:
https://doi.org/10.1532/hsf.4301Keywords:
thrombosis, emergency, mechanical valveAbstract
Background: Valve thrombosis is a potentially lethal complication of mechanical cardiac valves. We examined the clinical characteristics as well as the early outcomes of patients undergoing emergency surgery for left-sided mechanical valve thrombosis.
Methods: Between January 2012 and May 2020, 104 consecutive patients were offered an emergency redo surgery for acute mechanical valve thrombosis. Ninety-seven of these patients were included in the current study.
Results: The mean age was 34.2 ± 10.3 years. Most of the patients were females (61 patients), and 27 patients (27.8%) were pregnant. The mitral valve was the site of thrombosis in 81 patients. Inadequate anticoagulation was found in 60.8% of patients. The overall early mortality was 32.9% (32 patients) with an operative mortality of 25.7%. Outcomes in the pregnant subgroup tended to be worst with a maternal mortality in the range of 37%, and with fetal and neonatal survival as low as 33.3%.
Conclusion: The overall mortality in cases of mechanical valve thrombosis warranting surgery remains high. Since inadequate anticoagulation seems to be one of the major precipitating factors, the current study highlights the need for improvements in anticoagulation practices. The use of tissue valves should also be contemplated more seriously in some younger patients, especially females expressing the desire for future pregnancies.
References
Ahn H, Kim K, Kim CK, Kim CY. 2008. Surgical management of mechanical valve thrombosis: Twenty-six years’ experience. J Korean Med Sci. 23: 378-82.
Al Halees Z. 2007. The choice of valve prosthesis: Are the guidelines for everyone? Asian Cardiovasc & Thorac Ann. 15(6): 457-58.
Buttard P, Bonnefoy E, Chevalier P, Marcaz PB, Robin J, Obadia JF, et al. 1997. Mechanical cardiac valve thrombosis in patients in critical hemodynamic compromise. Eur J Cardiothorac Surg. 11: 710-13.
Choudhary SK, Talwar S, Airan B. 2016. Choice of prosthetic valve in a developing country. Heart Asia. 8(1): 65-72.
Durrleman N, Pellerin M, Bouchard D, Hebert Y, Cartier R, Perrault LP, et al. 2004. Prosthetic valve thrombosis: Twenty-year experience at the Montreal Heart Institute. J Thorac Cardiovasc Surg. 127: 1388-92.
El-Aroussy W, EL-Hagracy N, Fawzy H, Zaher S, Taha N, Moustafa S. 2013. Prevalence of rheumatic valvular heart disease among Egyptian school children: an echocardiographic screening. Med J Cairo Univ. 81(1): 139-144.
Elassy SM, Elmidany AA, Elbawab HY. 2014. Urgent cardiac surgery during pregnancy: a continuous challenge. Ann Thorac Surg. 97:1624-29.
Elsayed AA, Abdelaal KM, Abdelghaffar M, Mohamed E, Mahran T, Ahmed M, et al. 2019. Poor outcome of surgical management of acute malfunctioning mechanical mitral valve during pregnancy. Should centers with limited resources find different options? Heart Surg Forum. 22(5): E405-10.
Hassouna A, El-Ghanam M, Moftah H, Samir K, Refaat K. 2020. Index of deterioration of patients with mechanical prosthetic heart valve thrombosis. The Cardiothorac Surgeon. 28: 23-34.
Heuvelman HJ, Arabkhani B, Cornette JM, Pieper PG, Borges AJ, Takkenberg JJ, et al. 2013. Pregnancy outocmes in women with aortic valve substitutes. Am J Cardiol. 111: 382-87.
Lawley CM, Algert CS, Ford JB, Nippita TA, Figtree GA, Roberts CL. 2014. Heart valve prostheses in pregnancy: outcomes for women and their infants. J am Heart Assoc. 3: e000953.
Ma W, Hou B, Abdurusul A, Gong D, Tang Y, Chang Q, et al. 2015. Dysfunction of mechanical heart valve prosthesis: experience with surgical management in 48 patients. J Thorac Dis. 7(12); 2321-29.
Martinell J, Jimenez A, Rabago G, Artiz V, Fraile J, Farre J. 1991. Mechanical cardiac valve thrombosis. Is thrombectomy justified? Circulation. 84(5): III70-5.
Meuris B, Verbeken E, Flameng W. 2005. Mechanical valve thrombosis in a chronic animal model: differences between monoleaflet and bileaflet vavles. J Heart Valv Dis. 14(1): 96-104.
Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA, et al. 2014. 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 129: e521–e643.
Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomstrom-Lundqvist C, CIfkova R, De Bonis M, et al. 2018. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J. 39:3165-3241.
Roudaut R, Roques X, Lafitte S, Choukroun E, Laborde N,Madona F, et al. 2003. Surgery for prosthetic valve obstruction. A single center study of 136 patients. Eur J Cardiothorac Surg. 24: 868-72.
Sharaf AY, Ibrahim A, Elhamami M. 2017. Knowledge and adherence to oral anticoagulant therapy among patients with mechanical heart valve prosthesis. IOSR J Nurs & Health Scien. 6 (3): 19-29.
Sillesen M, Hjortdal V, Vejlstrup N, Sorensen K. 2011. Pregnancy with prosthetic heart valves – 30 years’ nationwide experience in Denmark. Eur J Cardioth Surg. 40:448-54.
Soler-Soler J, Galve E. 2000. Worldwide perspective of valve disease. Heart. 83: 721-25.
Tsai KT, Lin PJ, Chang CH, Chu JJ, Chang JP, Kao Cl, et al. 1993. Surgical management of thrombotic disc valve. Ann Thorac Surg. 55: 98-101.
Van Hagen IM, Roos-Hesselink JW, Ruys TP, Merz WM, Goland S, Gabriel H, et al. 2015. Pregnancy in women with a mechanical heart valve: Data of the European Society of Cardiology Registry of Pregnancy and Cardiac Disease (ROPAC). Circulation. 132: 132-42.
Vause S, Clarke B, Tower CL, Hay C, Knight M. 2017. Pregnancy outcomes in women with mechanical prosthetic heart valves: A prospective descriptive population based study using the United Kingdom Obstetric Surveillance System (UKOSS) data collection system. BJOG. 124: 1411-19.
Williams MA, Crause L, Van Riet S. 2004. A comparison of mechanical valve performance in a poorly anticoagulated community. J Card Surg. 19: 410-14.
Yin W, Krukenkamp IB, Saltman AE, Gaudette G, Suresh K, Bernal O, et al. 2006. Thrombogenic performance of a St Jude bileaflet mechanical heart valve in a sheep model. ASAIO J. 52(1): 28-33.