Metagenomic Next-Generation Sequencing in the Diagnosis of Deep Sternal Wound Infection After Cardiac Transplantation: A Case Report and Literature Review

Authors

  • Jiongbiao Yu Department of General Surgery, The First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, China
  • Rongjie Wu Department of Orthopedics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
  • Bing Xiong Department of Burns and Wound Repair Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
  • Zhifeng Huang Department of Burns and Wound Repair Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
  • Hanhua Li Department of Burns and Wound Repair Surgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

DOI:

https://doi.org/10.1532/hsf.4169

Keywords:

metagenomics next-generation sequencing, cardiac transplantation, deep sternal wound infection

Abstract

Purpose: To explore the value of metagenomics next-generation sequencing (mNGS) for deep sternal wound infection (DSWI) diagnosis.

Methods: mNGS was used to diagnose DSWI after cardiac transplantation; DSWI was treated with surgical debridement, wound care, and antibiotic therapy guided by mNGS.

Results: Coinfection of methicillin-resistant
Staphylococcus aureus (MRSA) and cytomegalovirus (CMV) was detected in this patient. The infection was controlled and the wound healed successfully with the specific medicine based on mNGS results for 3 weeks.

Conclusion: mNGS is effective to achieve precise, individualized, and rapid treatment for wound infection.

References

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Published

2021-12-14

How to Cite

Yu, J., Wu, R., Xiong, B., Huang, Z. ., & Li, H. (2021). Metagenomic Next-Generation Sequencing in the Diagnosis of Deep Sternal Wound Infection After Cardiac Transplantation: A Case Report and Literature Review. The Heart Surgery Forum, 24(6), E1015-E1017. https://doi.org/10.1532/hsf.4169

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