Interleukin 6 Activity Associated with a Cardiac Lymphoma

  • Mario Chiavarelli
  • Emma Borrelli
  • Fabrizio Gandolfo


Primary cardiac B-cell lymphoma is an extremely rare heart tumor that may be difficult to diagnose because of nonspecific clinical manifestations. Cardiac myxomas and mediastinal lymphomas show increased levels of serum cytokines, which correlate with symptoms and tumor size. We present a case of an intracardiac large B-cell lymphoma in a 75-year-old woman who had high serum levels of interleukin 6 that decreased after tumor excision. These data suggest a possible correlation between cardiac B lymphoma symptoms and interleukin 6 overproduction.


Frizzera G. 1988. Castleman's disease and relative disorders. Semin Diagn Pathol 5:346-64.\nLam KY, Dickens P, Chan AC. 1993. Tumors of the heart. A 20-year experience with a review of 12,485 consecutive autopsies. Arch Pathol Lab Med 117:1027-31.\nMochizuki Y, Okamura Y, Iida H, Mori H, Shimada K. 1998. Interleukin-6 and "complex" cardiac myxoma. Ann Thorac Surg 66:931-3.\nNacinovi?-Duleti? A, Stifter S, Dvornik S, Skunca Z, Jonji? N. 2008. Correlation of serum IL-6, IL-8 and IL-10 levels with clinicopathological features and prognosis in patients with diffuse large B-cell lymphoma. Int J Lab Hematol 30:230-9.\nYee C, Biondi A, Wang XH, et al. 1989. A possible autocrine role for interleukin-6 in two lymphoma cell lines. Blood 74:798-804.\n
How to Cite
Chiavarelli, M., Borrelli, E., & Gandolfo, F. (2010). Interleukin 6 Activity Associated with a Cardiac Lymphoma. The Heart Surgery Forum, 13(2), E129-E130.