Predictors of Mortality in Primary Surgical Repair of Postinfarction Ventricular Septal Defects: The Leipzig Experience

Authors

  • Maximilian Vondran, MD University Department for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
  • Jens Garbade, MD, PhD University Department for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
  • Sven Lehmann, MD, PhD University Department for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
  • Johannes Laessing Institute of Sports Medicine & Prevention, Faculty of Medicine, University of Leipzig, Leipzig, Germany
  • Mahmoud S. Wehbe, MD Department of Cardiac Surgery, Schuechtermann-Klinik, Bad Rothenfelde, Germany
  • Ardawan J. Rastan, MD, PhD Department of Cardiac and Vascular Thoracic Surgery, Philipps-University Hospital Marburg, Marburg, Germany
  • Michael A. Borger, MD, PhD University Department for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
  • Thomas Schroeter, MD University Department for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany

DOI:

https://doi.org/10.1532/hsf.3803

Keywords:

acute myocardial infarction, cardiogenic shock, coronary artery disease, ventricular septal defect, mechanical complications, cardiac surgery, high risk

Abstract

Background: A postinfarction ventricular septal defect (pVSD) as a complication of acute myocardial infarction (AMI) is associated with high mortality. This retrospective, single-center study aimed to identify predictors of early and long-term outcomes in patients undergoing primary surgical repair of pVSD managed by various surgical techniques.

Methods: We reviewed data from 77 consecutive patients who underwent primary surgical repair after pVSD in our institution. Prospectively collected demographic and perioperative data were analyzed retrospectively. Predictors of 30-day mortality and long-term outcome were assessed.

Results: pVSD was anterior in 45 patients (58.4%) and posterior in 32 (41.6%). Buttressed mattress suture (n = 9, 11.7%), simple single septal patch (n = 34, 44.2%), simple double septal patch (n = 2, 2.6%), sandwich double patch (n = 1, 1.3%), and the infarct exclusion technique (n = 31, 40.3%) were performed for surgical closure. Fifty-three patients (68.8%) had preoperative cardiogenic shock. The 30-day mortality was 42.8% (33 patients). Independent risk factors of 30-day mortality were duration between AMI and surgery <7 days (odds ratio [OR] 5.229, P = .011), preoperative absence of diuretics (OR 6.913, P = .005), and preoperative cardiogenic shock (OR 3.558, P = .011). Cumulative survival rates at 1, 5, and 10 years were 57.1%, 57.1%, and 31.2%, respectively.

Conclusion: In pVSD, the 30-day mortality remains high, and preoperative cardiogenic shock significantly influenced mortality in our study. None of the surgical techniques or materials used in our investigation influenced the outcome.

Author Biography

Johannes Laessing, Institute of Sports Medicine & Prevention, Faculty of Medicine, University of Leipzig, Leipzig, Germany

University Department for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany

Institute of Sports Medicine & Prevention, Faculty of Medicine, University of Leipzig, Leipzig, Germany

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Published

2021-06-11

How to Cite

Vondran, M., Garbade, J., Lehmann, S., Laessing, J. ., Wehbe, M. S. ., Rastan, A., Borger, M. ., & Schroeter, T. (2021). Predictors of Mortality in Primary Surgical Repair of Postinfarction Ventricular Septal Defects: The Leipzig Experience. The Heart Surgery Forum, 24(3), E522-E529. https://doi.org/10.1532/hsf.3803

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Articles