Colchicine for Coronary Heart Disease: A Meta-Analysis of Randomized Controlled Trials


  • Chunfeng Liao Department of Cardiology, The First Hospital Of Changsha, Hunan Province, China
  • Ping Liu Department of Respiratory and Critical Care Medicine, The First Hospital Of Changsha, Hunan Province, China
  • Yun Zhou Department of Orthopedics, The First Hospital Of Changsha, Hunan Province, China
  • Di Lu Department of Ultrasound, Dianjiang County Hospital of Traditional Chinese Medicine, Chongqing
  • Qi Wu Department of Critical Care Medicine, The First Hospital Of Changsha, Hunan Province, China



colchicine, myocardial infarction, percutaneous coronary intervention (PCI), randomized controlled trials


Background: The efficacy of colchicine administration for coronary heart disease remains controversial. We conducted a systematic review and meta-analysis to explore the influence of colchicine administration versus placebo on treatment efficacy for coronary heart disease.

Methods: We have searched PubMed, Embase, Web of Science, EBSCO, and Cochrane Library databases through May 2021 for randomized controlled trials (RCTs) assessing the effect of colchicine administration versus placebo in patients with coronary heart disease. This meta-analysis was performed using the random-effects model.

Results: Six RCTs involving 6,321 patients were included in the meta-analysis. Overall, compared with control groups for coronary heart disease, colchicine intervention can significantly reduce major adverse cardiovascular events (odds ratio [OR] 0.74; 95% confidence interval [CI] 0.59 to 0.92; P = .006), but revealed no obvious impact on mortality (OR=0.93; 95% CI=0.63 to 1.36; P = .69), serious adverse events (OR 0.71; 95% CI 0.31 to 1.61; P = .41), or restenosis (OR 1.02; 95% CI 0.63 to 1.64; P = .95).

Conclusions: Colchicine treatment may be effective to reduce major adverse cardiovascular events in patients with coronary heart disease.


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How to Cite

Liao, C., Liu, P., Zhou, Y., Lu, D., & Wu, Q. (2021). Colchicine for Coronary Heart Disease: A Meta-Analysis of Randomized Controlled Trials. The Heart Surgery Forum, 24(5), E863-E867.