The High-Sensitivity C-Reactive Protein to Prealbumin Ratio Predicts Adverse Cardiovascular Events after ST-Elevation Myocardial Infarction

Authors

  • Hongqiang Ren Cardiovascular Center, Suining Central Hospital, Suining, China
  • Li Zhao Cardiovascular Center, Suining Central Hospital, Suining, China
  • Yijun Liu Cardiovascular Center, Suining Central Hospital, Suining, China
  • Zhen Tan Cardiovascular Center, Suining Central Hospital, Suining, China
  • Guiquan Luo Cardiovascular Center, Suining Central Hospital, Suining, China
  • Xuejun Deng Cardiovascular Center, Suining Central Hospital, Suining, China

DOI:

https://doi.org/10.1532/hsf.3307

Keywords:

ST-elevation myocardial infarction, major adverse cardiac events, high sensitivity C-reactive protein to prealbumin ratio, biomarker

Abstract

Background: This study evaluated the association of the high-sensitivity C-reactive protein to prealbumin ratio (CPR) with adverse cardiovascular events after ST-elevation myocardial infarction (STEMI) in patients undergoing primary percutaneous coronary intervention (PCI).

Methods: The study included 682 patients who presented with STEMI and were treated with primary PCI. Patients were divided into 2 groups: high CPR (CPR ≥0.02) and low CPR (CPR <0.02). The primary endpoint of the study was the occurrence of major adverse cardiovascular events (MACE), defined as cardiovascular mortality or admission due to recurrent AMI or heart failure. Multivariate Cox regression models were used to assess the prognostic value of CPR on MACE in patients with STEMI.

Results: During a median follow-up of 18 months, the accumulated incidence rate of MACE was significantly higher in the high-CPR group than in the low-CPR group (38.7% versus 12.0%, P < .01). Multivariate analysis revealed that CPR was an independent predictor for increased risk of MACE (hazard ratio = 3.27, 95% confidence interval [CI] 2.14 to 4.49, P < .01). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve for predicting the diagnosis of MACE was higher for CPR (0.82, 95% CI 0.77 to 0.87) than hs-CRP (0.70, 95% CI 0.65 to 0.75).

Conclusion: CPR was independently associated with MACE and can be used for risk stratification in patients with STEMI.

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Published

2021-02-16

How to Cite

Ren, H. ., Zhao, L. ., Liu, Y. ., Tan, Z. ., Luo, G. ., & Deng, X. (2021). The High-Sensitivity C-Reactive Protein to Prealbumin Ratio Predicts Adverse Cardiovascular Events after ST-Elevation Myocardial Infarction. The Heart Surgery Forum, 24(1), E153-E157. https://doi.org/10.1532/hsf.3307

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