Circulating microRNA-21 as Stable Blood-Based Markers for Patients With ISR After PCI


  • Xiong Zhang Department of Laboratory, the First People’s Hospital of Xian Yang City, Shaanxi Province, China
  • Xiao-Ping Xiao Department of Laboratory, the Eighth Hospital of Xi An City, Shaanxi Province, China
  • Xu- Ai Ren Department of Cardiology, the First People’s Hospital of Xian Yang City, Shaanxi Province, China
  • Wei Xue Department of Blood Transfusion, the First People’s Hospital of Xian Yang City, Shaanxi Province, China



In-stent restenosis, Percutaneous coronary interention, MiR-21, Intravascular ultrasound, Inflammation, proliferation, Ischemic heart disease


It recently has been reported that the in-stent restenosis (ISR) of expanded area after percutaneous coronary intervention (PCI) within six months can become a serious postoperative complication. A real-time quantitative PCR was used to analyze the expression of serum miR-21 in 33 ISR and 37 non-ISR patients after PCI. Expression of miR-21 was significantly higher in the ISR group compared with that in the NISR group, and a similar trend also occurred in factor- (TNF-α) level, Interleukin -6 (IL-6) level, and plaque area (PLA). However, a contrary trend occurred in the external elastic membrane area (EEM) and minimal lumen area (MLA). This study suggests that the increased expression of serum miR-21 is related to ISR after PCI, and miR-21 can be a new predictor of ISR.


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How to Cite

Zhang, X., Xiao, X.-P., Ren, X.-. A. ., & Xue, W. (2020). Circulating microRNA-21 as Stable Blood-Based Markers for Patients With ISR After PCI. The Heart Surgery Forum, 23(6), E756-E762.