Exploring Potential Proteomic Biomarkers for Prognosis of Infective Endocarditis through Profiled Autoantibodies by an Immunomics Protein Array Technique

Protein Biomarkers for Infective Endocarditis

Authors

  • Chang-Hua Chen Division of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan
  • Ying-Cheng Chen Division of Cardiovascular Surgery, Changhua Christian Hospital, Taiwan
  • Ching-Hui Huang Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan
  • Shu-Hui Wang Division of Critical Care Medicine, Changhua Christian Hospital, Changhua, Taiwan
  • Jen-Shiou Lin Department of Laboratory Medicine, Changhua Christian Hospital, Changhua, Taiwan
  • Shou-Chen Lo Department of Life Sciences, National Chung Hsing University, Taichung County, Taiwan
  • Chieh-Chen Huang Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung County, Taiwan

DOI:

https://doi.org/10.1532/hsf.3017

Keywords:

Infective endocarditis , protein array, prognostic biomarkers

Abstract

Though infective endocarditis (IE) is a life-threatening cardiac infection with a high mortality rate, the effective diagnostic and prognostic biomarkers for IE are still lacking. The aim of this study was to explore the potential applicable proteomic biomarkers for IE through the Immunome™ Protein Array system. The system was employed to profile those autoantibodies in IE patients and control subjects. Our results showed that interleukin-1 alpha (IL1A), nucleolar protein 4 (NOL4), tudor and KH domain-containing protein (TDRKH), G antigen 2B/2C (GAGE2), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and X antigen family member 2 (XAGE2) are highly differentially-expressed among IE and non-IE control. Furthermore, bactericidal permeability-increasing protein (BPI), drebrin-like protein (DBNL), signal transducing adapter molecule 2 (STAM2), cyclin-dependent kinase 16 (CDK16), BAG family molecular chaperone regulator 4 (BAG4), and nuclear receptor-interacting protein 3 (NRIP3) are differentially-expressed among IE and healthy controls. On the other hand, those previously identified biomarkers for IE, including erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, procalcitonin, and N-terminal-pro-B-type natriuretic peptide demonstrated only minor significance. With scientific rationalities for those highly differentially-expressed proteins, they could serve as potential candidates for diagnostic biomarkers of IE for further analysis.

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Published

2020-08-05

How to Cite

Chen, C.-H., Chen, Y.-C. ., Huang , C.-H., Wang, . S.-H. ., Lin, J.-S. ., Lo, S.-C., & Huang, C.-C. (2020). Exploring Potential Proteomic Biomarkers for Prognosis of Infective Endocarditis through Profiled Autoantibodies by an Immunomics Protein Array Technique: Protein Biomarkers for Infective Endocarditis. The Heart Surgery Forum, 23(5), E555-E573. https://doi.org/10.1532/hsf.3017

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Articles