Impact of Glycosylated Hemoglobin on the Prognosis of Patients with Acute Ischemic Stroke Treated with Arterial Thrombolysis

Authors

  • Wentong Ling Department of Neurology, Zhongshan City People’s Hospital, Zhongshan, China
  • Qiong Chen Department of Clinical Medicine, Zhongshan City People’s Hospital, Zhongshan, China
  • Pu Huang Department of Neurology, Zhongshan City People’s Hospital, Zhongshan, China
  • Dengke Han Department of Clinical Medicine, Zhongshan City People’s Hospital, Zhongshan, China
  • Wenjun Wu Department of Neurology, Zhongshan City People’s Hospital, Zhongshan, China

DOI:

https://doi.org/10.1532/hsf.2929

Keywords:

arterial thrombolysis, acute ischemic stroke, glycosylated hemoglobin

Abstract

Background: To investigate the impact of glycosylated hemoglobin (HbA1c) on the prognosis of patients with acute ischemic stroke (AIS) treated with intra-arterial thrombolysis (IAT).

Methods: The clinical data of 136 patients with AIS treated with IAT at the Zhongshan City People’s Hospital were retrospectively analyzed. The patients were divided into a high HbA1c group (HHbA1c) (≥6.5%) and a normal HbA1c group (NHbA1c) (<6.5%). According to National Institutes of Health Stroke Scale (NIHSS) score after thrombolysis, patients were divided into a good prognosis group (GP) (≥4 or <4 points reduction) and a poor prognosis group (PP) (≤4 or >4 points reduction).

Results: There were significant differences in the HbA1c and glucose levels, NIHSS scores at admission and at discharge, complication rates, and mortality rates between groups HHbA1c and NHbA1c (P < .05) and between groups GP and PP (P < .05). The multivariate logistic regression analysis showed that HbA1c level (odds ratio [OR] 0.717; 95% confidence interval [CI] 0.545 to 0.889) and NIHSS score at admission (OR 0.894; 95% CI 0.814 to 0.982) were risk factors for neurological improvement in IAT-treated patients with AIS.

Conclusions: HbA1c level is associated with neurological function improvement in IAT-treated patients with AIS and can be used as a serological indicator of poor prognosis.

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Published

2020-07-02

How to Cite

Ling, W., Chen, Q., Huang, P., Han, D., & Wu, W. (2020). Impact of Glycosylated Hemoglobin on the Prognosis of Patients with Acute Ischemic Stroke Treated with Arterial Thrombolysis. The Heart Surgery Forum, 23(4), E447-E451. https://doi.org/10.1532/hsf.2929

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Articles