Surgical Treatment of Primary Cardiac Tumor Associated with Malignant Arrhythmias
Objective: Pediatric primary cardiac tumor is an extremely rare disease. The tumor can extend into the conduction system and cause malignant arrhythmias. We retrospectively reviewed 6 consecutive cases of children with primary cardiac tumor that manifested as rhythm disturbance.
Methods: In our center, 6 children were enrolled from October 2009 to August 2016. Detailed operative data and follow-up information were comprehensively collected and statistically analyzed.
Results: The patients were ages 1 to 16 years and weighed 7.9 to 44.5 kg. Preoperative ventricular tachycardia was present in 3 patients, frequent ventricular ectopic beats in 1 patient, supraventricular tachycardia in 1 patient, and atrial flutter in 1 patient. All 6 patients underwent a complete tumor resection. The tumors were localized in the left ventricular free wall (3 patients), left ventricular outflow tract (1 patient), left atrium (1 patient), and right atrium (1 patient). One patient received 2 radiofrequency ablation procedures before tumor resection. Postoperative sick sinus syndrome occurred in 1 patient because the tumor infiltrated the sinoatrial node. Tumors from 2 patients were pathologically diagnosed as fibroma and 4 as rhabdomyoma.
Reoperation of mitral valve repair was performed in 1 patient 1 year after tumor resection. The mean (± SD)
follow-up time was 63.7 ± 31.4 months, and all children were well, with Ross functional classification I and no signs of recurrence or metastasis.
Conclusions: In conclusion, cardiac tumor is a rare but nonneglectable reason for arrhythmia, and surgical resection is the optimal procedure, with satisfactory results.
Delmo Walter EM, Javier MF, Sander F, Hartmann B, Ekkernkamp A, Hetzer R. Primary cardiac tumors in infants and children: Surgical strategy and long-term outcome. Ann Thorac Surg. 2016; 102(6):2062-2069.
Isaacs JH. Fetal and neonatal cardiac tumors. Pediatr Cardiol. 2004; 25:252-273.
Kwiatkowska J, Wałdoch A, Meyer-Szary J, Potaż P, Grzybiak M. Cardiac tumors in children: A 20-year review of clinical presentation, diagnostics and treatment. Adv Clin Exp Med. 2017; 26(2):319-326.
Miyake CY, Del Nido PJ, Alexander ME, et al. Cardiac tumors and associated arrhythmias in pediatric patients, with observations on surgical therapy for ventricular tachycardia. J Am Coll Cardiol. 2011; 58(18):1903-1909.
Nadas AS, Ellison RC. Cardiac tumors in infancy. Am J Cardiol .1968; 21:363-366.
Padalino MA, Vida VL, Boccuzzo G, et al. Surgery for primary cardiac tumors in children: Early and late results in a multicenter European Congenital Heart Surgeons Association study. Circulation. 2012; 126(1):22-30.
Shi L, Wu L, Fang H, et al. Identification and clinical course of 166 pediatric cardiac tumors. Eur J Pediatr. 2017; 176(2):253-260.
Tzani A, Doulamis IP, Mylonas KS, Avgerinos DV, Nasioudis D. Cardiac tumors in pediatric patients: A systematic review. World J Pediatr Congenit Heart Surg. 2017; 8(5):624-632.
Wang ZF, Yin Q, Yang Y, et al. Clinical analysis of 48 cases of cardiac neoplasm. Chinese J ournal of Extracorporeal Circulation. 2016; 14(4):226-228.
Xu Z, Wu Q, Li H, Zhang M. Surgical resection of giant left ventricular fibromas in children. J Card Surg. 2017; 32(10):662-664.
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