Comparison of Platelet Mass Index in On-Pump and Off-Pump Coronary Artery Bypass Surgery
DOI:
https://doi.org/10.1532/hsf.2803Keywords:
Platelet Mass Index, Coronary Artery, bypass, Off-PumpAbstract
Introduction: Platelet mass index (PMI) is calculated by multiplying platelet count and mean platelet volume (MPV). It demonstrates platelet activation and is thought to be associated with inflammation. Its importance for cardiac surgery has not yet fully been clarified. This study investigates whether there is a difference between PMI levels after on-pump and off-pump coronary artery bypass surgery and the relationship between early postoperative complications and PMI.
Method: In our hospital, 138 patients were included in the study retrospectively. The patients were divided into
2 groups: Group 1 (on-pump) with 80 patients (22 females,
58 males, mean age 61.54 ± 8.68) and Group 2 (off-pump) with 58 patients (15 females, 43 males, mean age 61.34 ± 10.04). In biochemical analysis, hemoglobin, platelet, white blood cell, and MPV values of the patients were evaluated in the biochemistry laboratory of our hospital with the blood taken preoperatively from the forearm veins and postoperatively on the first, third, and seventh days and, on average, after the first month.
Results: There was a statistically significant difference between postoperative first day thrombocyte (K/µL) (P = .005), postoperative first day PMI (P = .014), postoperative first day leukocyte (K/µL) (P = .001), postoperative first day Hb (g/dL) (P = .001), postoperative third day thrombocyte (K/µL) (P = .003), postoperative third day PMI (P = .031), postoperative third day leukocyte (K/µL) (P = .004), and postoperative seventh day leukocyte (K/µL) (P = .002). There was no meaningful relationship between PMI and early postoperative complications.
Conclusion: We think PMI is a more valuable indicator than MPV as an inflammation marker in cardiac surgery. In our opinion, PMI is a cheap and valuable inflammation marker that can be used in coronary surgery that can be obtained from routine hemogram test and can easily be evaluated.
References
Akpinar I, Sayin MR, Gursoy YC, Karabag T, Kucuk E, Buyukuysal MC, et al. 2014. Plateletcrit: a platelet marker associated with saphenous vein graft disease. Herz 39(1): 142-8.
Boos CJ, Lip GY. 2007. Assessment of mean platelet volume in coronary artery disease–what does it mean? Thromb Res. 120(1): 11-3.
Braekkan SK, Mathiesen EB, Njølstad I, Wilsgaard T, Størmer J, Hansen JB. 2010. Mean platelet volume is a risk factor for venous thromboembolism: the tromso study, tromso, Norway. J Thromb Haemost. 8(1):157-62.
Çakmak AH, Enhoş A, Ertürk M, Kalkan KA, Satılmışoğlu HM, Gül M. 2016. Association between New Platelet Indices and Calcific Aortic Stenosis: Plateletcrit and Platelet to Lymphocyte Ratio. Van Med J. 23(4): 330-7.
Christen S, Finckh B, Lykkesfeldt J, Gessler P, Frese-Schaper M, Nielsen P, et al. 2005. Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation. Free Radic Biol Med. 38(10):1323–32.
Demir N, Peker E, Ece İ, Ağengin K, Bulan KA, Tuncer O. 2016. Is platelet mass a more significant indicator than platelet count of closure of patent ductus arteriosus? J Matern Fetal Neonatal Med. 29(12):1915-8.
Franco AT, Corken A, Ware J. 2015. Platelets at the interface of thrombosis, inflammation, and cancer. Blood. 126(5):582-8.
Girgin R, Cinar O, Bulut E, Akduman B, Mungan NA. 2018. The Role Of The Platelet Mass İndex (PMI) As A New Prognostic Factor İn Fourneir’s Gangrene. African Journal Of Urology. 24:226-32.
Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. 2004. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke. 35(7):1688-91.
Kahvecioglu D, Erdeve O, Akduman H, Ucar T, Alan S, Çakır U, et al. 2018. Influence of platelet count, platelet mass index, and platelet function on the spontaneous closure of ductus arteriosus in the prematurity. Pediatr Neonatol. 59(1):53-7.
Korkmaz L, Baştuğ O, Ozdemir A, Korkut S, Karaca C, Akin MA, et al. 2017. The efficacy of propranolol in retinopathy of prematurity and its correlation with the platelet mass index. Curr Eye Res. 42(1):88-97.
Laffey JG, Boylan JF, Cheng DC. 2002. The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist. Anesthesiology. 97(1):215–52.
Langer HF, Gawaz M. 2008. Platelet-vessel wall interactions in atherosclerotic disease. Thromb Haemost. 99(3): 480-6.
Lehmann S, Dieterlen MT, Flister A, Klaeske K, Jawad K, Garbade J, et al. 2019. Differences of early immunological responses in on-pump versus off-pump cardiac surgery. Perfusion. 34(5):399-407.
Li JY, Li Y, Jiang Z, Wang RT, Wang XS. 2014. Elevated mean platelet volume is associated with presence of colon cancer. Asian Pac J Cancer Prev. 15(23):10501-4.
Lisman T. 2018. Platelet–neutrophil interactions as drivers of inflammatory and thrombotic disease. Cell Tissue Res. 371(3):567-76.
Okur N, Buyuktiryaki M, Uras N, Oncel MY, Ertekin O, Canpolat FE et al. 2016. Platelet mass index in very preterm infants: can it be used as a parameter for neonatal morbidities? J Matern Fetal Neonatal Med. 29(19): 3218-22.
Omar M, Tanriverdi O, Cokmert S, Oktay E, Yersal O, Pilancı KN, et al. 2018. Turkish Descriptive Oncological Researches Group. Role of increased mean platelet volume (MPV) and decreased MPV/platelet count ratio as poor prognostic factors in lung cancer. Clin Respir J. 12(3):922-29.
Paparella D, Yau TM, Young E. 2002. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur J Cardiothorac Surg. 21(2):232-44.
Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO 3rd, Criqui M, et al. 2003. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 107(3):499–511.
Wachowicz B, Morel A, Miller E, Saluk J. 2016. The physiology of blood platelets and changes of their biological activities in multiple sclerosis. Acta Neurobiol Exp (Wars). 76(4):269-81.
Yoon SS, Bang JH, Jeong SS, Jeong JH, Woo JS. 2017. Risk Factors of On-Pump Conversion during Off-Pump Coronary Artery Bypass Graft. Korean J Thorac Cardiovasc Surg. 50(5):355-62.
Zakkar M, Ascione R, James AF, Angelini GD, Suleiman MS. 2015. Inflammation, oxidative stress and postoperative atrial fibrillation in cardiac surgery. Pharmacol Ther. 154:13-20.10. Zakkar M, Guida G, Suleiman MS, Angelini GD. 2015. Cardiopulmonary bypass and oxidative stress. Oxid Med Cell Longev. 2015:189863.
Zhang Z, Xu X, Ni H, Deng H. 2014. Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care 29(5):885.e1-6.
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