Minimally Invasive CABG or Hybrid Coronary Revascularization for Multivessel Coronary Diseases: Which Is Best? A Systematic Review and Metaanalysis

A systematic review and meta-analysis

  • Zhiyuan Guan Department of Cardiology Surgery, Peking University Third Hospital, Haidian District, Beijing, China
  • Zhe Zhang Department of Cardiology Surgery, Peking University Third Hospital, Haidian District, Beijing, China
  • Kaiyun Gu Department of Cardiology Surgery, Peking University Third Hospital, Haidian District, Beijing, China
  • Heqing Wang Department of Cardiology Surgery, Peking University Third Hospital, Haidian District, Beijing, China
  • Jin Lin Department of Cardiology Surgery, Peking University Third Hospital, Haidian District, Beijing, China
  • Wenjun Zhou Department of Cardiology Surgery, Peking University Third Hospital, Haidian District, Beijing, China
  • Feng Wan Department of Cardiology Surgery, Peking University Third Hospital, Haidian District, Beijing, China
Keywords: Minimally invasive coronary revascularization;hybrid coronary revascularization;meta-analysis

Abstract

Objectives: Minimally invasive coronary revascularization (MICR) involves minimally invasive direct coronary artery bypass grafting (MIDCAB) and robotic-assisted coronary artery bypass grafting (RCABG), and hybrid coronary revascularization (HCR) aims to combine MICR/RCABG on left anterior descending (LAD) and percutaneous coronary interventions (PCI) on non-LAD lesions. We performed a systematic review and metaanalysis to compare clinical outcome after MICR and HCR.

Methods: A metaanalysis was carried out through searching PubMed, EMBASE, Web of Science, and Medline for comparative studies evaluating the primary and secondary clinical end points.

Results: A systematic literature search identified 8 observational studies that satisfied our inclusion criteria, including being suitable for metaanalysis; the studies were between 1990 and 2018 and included 1084 cases of HCR and 2349 cases of MICR. Metaanalysis of these studies showed that HCR was associated with a reduced need for ICU LOS (WMD –11.46 hours, 95% CI, –18.76 ~ –4.25, P = .02), to hospital time (WMD –1.34 hours, 95% CI, –2.42 to 0.26, P < .01), and blood transfusion (OR 0.43, 95% CI, 0.31-0.59, P < .00001) than MICR. Comparisons of individual components showed no significant difference in terms of in-hospital mortality, MACCE, shock, myocardial infarction (MI), long-term survival, total variable cost, and surgical complications (including renal failure, chest drainage, bleeding).

Conclusions: HCR was noninferior to MICR in terms of in-hospital mortality, MACCE, shock, MI, long-term survival, total variable cost, and surgical complications (including renal failure, chest drainage, bleeding), whereas HCR was associated with a reduced need for ICU LOS, hospital time, and blood transfusion than MICR and less infection than MICR. Further randomized studies are warranted to corroborate these observational data.

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Published
2019-12-20
How to Cite
Guan, Z., Zhang, Z., Gu, K., Wang, H., Lin, J., Zhou, W., & Wan, F. (2019). Minimally Invasive CABG or Hybrid Coronary Revascularization for Multivessel Coronary Diseases: Which Is Best? A Systematic Review and Metaanalysis. The Heart Surgery Forum, 22(6), E493-E502. https://doi.org/10.1532/hsf.2499
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Articles