The Efficacy of Mesenchymal Stem Cells for Cardiomyopathy: A Meta-analysis of Randomized Controlled Trials

  • Yu Li Intensive Care Unit, Wenzhou People’s Hospital, Wenzhou, Zhejiang Province, P.R. China
  • Linglong Chen Intensive Care Unit, Wenzhou People’s Hospital, Wenzhou, Zhejiang Province, P.R. China
  • Sheng Li Intensive Care Unit, Wenzhou People’s Hospital, Wenzhou, Zhejiang Province, P.R. China
  • Ya-Jing Pan Intensive Care Unit, Wenzhou People’s Hospital, Wenzhou, Zhejiang Province, P.R. China
  • Peiyun Peng
  • Yunfeng Xia The First Affiliated Hospital of Chongqing Medical University

Abstract

Introduction: The efficacy of mesenchymal stem cells (MSCs) for cardiomyopathy remains controversial. We conducted a systematic review and meta-analysis to explore the influence of MSCs versus placebo on the treatment efficacy of cardiomyopathy.

Methods: We searched PubMed, EMbase, Web of Science, EBSCO, and Cochrane Library databases through November 2018 for randomized controlled trials (RCTs) assessing the treatment efficacy of MSCs versus placebo for cardiomyopathy. This meta-analysis was performed using the random-effect model.

Results: Five RCTs were included in the meta-analysis. Overall, compared with the control group for cardiomyopathy, MSCs treatment showed significantly positive effect on LVEF (MD = 5.85; 95% CI = 3.88 to 7.83; P < .00001), NYHA classification (MD = -1.11; 95% CI = -1.45 to -0.77; P < .00001), LVEDd (MD = -3.00; 95% CI = -5.37 to -0.64;
P = .01), and the proportion of fixed defects (MD = -4.22; 95% CI = -6.91 to -1.52; P = .002), but had no obvious influence on death (RR = 0.42; 95% CI = 0.12 to 1.50; P = 0.18) or adverse events (RR = 1.14; 95% CI = 0.70 to 1.86; P = .59).

Conclusion: MSCs treatment showed favorable impact on LVEF, NYHA classification, LVEDd, and the proportion of fixed defects for cardiomyopathy patients.

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Published
2019-06-05
Section
Articles