Does Acute Aortic Dissection Display Seasonal Variation?


  • Murat Bulent Rabus
  • Ercan Eren
  • Korhan Erkanli
  • Mete Alp
  • Cevat Yakut



Background: The relation between cardiovascular diseases and the seasons is well known; however, only a few reports have addressed the seasonal aspects of acute aortic dissections. We investigated whether presentation of acute aortic dissection has monthly/seasonal variations.

Methods: From February 1985 to January 2006, 165 consecutive patients with aortic dissection admitted to our institution were reviewed. During this period, regional monthly atmospheric pressure data were supplied by the state's meteorological service. The mean and SD of atmospheric pressure data were analyzed statistically.

Results: The frequency of acute aortic dissection was found to be significantly higher during winter versus other seasons (P = .041). A relatively high positive correlation was found between the incidence of acute aortic dissection and the mean atmospheric pressure (P = .037). The study confirmed monthly variation with a peak in January. In winter, the frequency of acute aortic dissection was higher in male than in female patients.

Conclusions: This study demonstrates that the occurrence of acute aortic dissection has significant seasonal/monthly variations. Thus, these observations may be a guide for prevention of acute aortic dissections by structuring treatment approaches with consideration given to the times of the year that patients are most vulnerable.


Ballaro A, Cortina-Borja M, Collin J. 1998. A seasonal variation in the incidence of ruptured abdominal aortic aneurysms. Eur J Vasc Endovasc Surg 15:429-31.nBown MJ, McCarthy MJ, Bell PR, et al. 2003. Low atmospheric pressure is associated with rupture of abdominal aortic aneurysms. Eur J Vasc Endovasc Surg 25:68-71.nBull JM, Brozovic M, Chakrabarti R, et al. 1979. Relationship of air temperature to various chemical, haematological, and haemostatic variables. J Clin Pathol 32:16-20.nBurnett RW, Itano M. 1989. An interlaboratory study of blood-gas analysis: dependence of pO2 and pCO2 results on atmospheric pressure. Clin Chem 35:1779-81.nBuxton N, Liu C, Dasic D, et al. 2001. Relationship of aneurismal subarachnoid haemorrhage to changes in atmospheric pressure: results of a prospective study. J Neurosurg 95:391-2.nHata T, Ogihara T, Maruyama A, et al. 1982. The seasonal variation of blood pressure in patients with essential hypertension. Clin Exp Hypertens 4:341-54.nKeatinge WR, Coleshaw ERK, Easton JC, et al. 1984. Increases in platelet and red cell counts, blood viscosity, and arterial pressure during mild surface cooling: factors in mortality from coronary and cerebral thrombosis in winter. Br Med J 289:10458.nKobza R, Ritter M, Seifert B, et al. 2002. Variable seasonal peaks for different types of aortic dissection? Heart 88:640.nKono T, Morita H, Nishina T, et al. 1996. Circadian variations of the onset of acute myocardial infarction and efficacy of thrombolytic therapy. J Am Coll Cardiol 27:774-8.nKunes J, Tremblay J, Bellavance F, et al. 1991. Influence of environmental temperature on the blood pressure of hypertensive patients in Montreal. Am J Hypertens 4:422-6.nLasica MR, Perunicic J, Mrdovic I, et al. 2006. Temporal variations at the onset of spontaneous acute aortic dissection. Int Heart J 47:585-95.nManfredini R, Gallerani M, Portaluppi F, et al. 1995. Circadian variation in the occurrence of paroxysmal supraventricular tachycardia in clinically healthy subjects. Chronobiol Int 12:55-61.nManfredini R, Gallerani M, Portaluppi F, et al. 1997. Chronobiological patterns of onset of acute cerebrovascular diseases. Thromb Res 88:451-63.nManfredini R, Portaluppi F, Zamboni P, et al. 1999. Circadian variation in spontaneous rupture of abdominal aorta. Lancet 353:643-4.nMehta RH, Manfredini R, Hassan F, et al. 2002. Chronobiological patterns of acute aortic dissection. Circulation 106:1110-5.nMinami J, Kawano Y, Ishimitsu T, et al. 1996. Seasonal variations in office, home and 24h ambulatory blood pressure in patients with essential hypertension. J Hyperten 14:14215.nRepanos C, Chadha NK. 2005. Is there a relationship between weather conditions and aortic dissection? BMC Surgery 5:21.nSchievink WI, Wijdicks EF, Kuiper JD. 1998. Seasonal pattern of spontaneous cervical artery dissection. J Neurosurg 89:101-3.nSterpetti AV, Cavallari N, Allegrucci P, et al. 1995. A seasonal variation in the incidence of ruptured abdominal aortic aneurysm. J R Coll Surg Edinb 40:14-5.nSumiyoshi M, Kojima S, Arima M, et al. 2002. Circadian, weekly and seasonal variation at the onset of acute aortic dissection. Am J Cardiol 89:619-23.nTaylor CR, Hodge EM, White DA. 1989. Circadian rhythms of angina: similarity to circadian rhythms of myocardial infarction, ischemic ST segment depression, and sudden cardiac death: the Amlodipine Angina Study Group. Am Heart J 118:1089-98.nWilmshurst P. 1994. Temperature and cardiovascular mortality. Br Med J 309:102930.nWoodhouse PR, Khaw KT, Plummer M, et al. 1994. Seasonal variations of plasma fibrinogen and factor VII activity in the elderly: winter infections and death from cardiovascular disease. Lancet 343:435.n



How to Cite

Rabus, M. B., Eren, E., Erkanli, K., Alp, M., & Yakut, C. (2009). Does Acute Aortic Dissection Display Seasonal Variation?. The Heart Surgery Forum, 12(4), E238-E240.