Predicting Value of Growth Differentiation Factor 15 and Its Correlations With Atrial Fibrillation

Authors

  • Jing Zhou, BS Department of Emergency, West China Hospital of Sichuan University, Chengdu, Sichuan, China
  • Zhefeng Kang, BS Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China
  • Lulu Liu, MS Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China
  • Yingqiang Guo, MD Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China
  • Sai Chen, MD Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China

DOI:

https://doi.org/10.1532/hsf.2355

Keywords:

GDF-15, atrial fibrillation, major bleeding, death

Abstract

Aims: Despite several clinical risk factors for atrial fibrillation (AF), some newly identified biomarkers may also potentially serve as risk factors for AF. However, none of these factors so far have been adopted in clinical practice. Recently, a number of studies with an attempt to identify the role of growth differentiation factor 15 (GDF-15) in AF have obtained ambiguous results. We try to identify the predicting role of GDF-15 in AF and AF-related complications with meta-analysis or systematic analysis.

Methods and results: We enrolled 10 studies, looking at the predicting role of GDF-15 in non-valvular AF using meta-analysis, summarized its role in AF-related major complications, and discussed whether it was dependable to forecast postoperative AF. It turned out that GDF-15 is an independent factor to predict occurrence of AF, while it remains obscure to directly demonstrate its relationship with postoperative AF. For AF patients on anti-platelet treatment, GDF-15 plays a critical role in predicting major bleeding, cardiovascular death and overall death, and improves the current predicting model.

Conclusions: Circulating GDF-15 greatly associates with AF and AF-related complications. It should be applied clinically.

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Published

2020-07-02

How to Cite

Zhou, J., Kang, Z., Liu, L., Guo, Y., & Chen, S. (2020). Predicting Value of Growth Differentiation Factor 15 and Its Correlations With Atrial Fibrillation. The Heart Surgery Forum, 23(4), E452-E460. https://doi.org/10.1532/hsf.2355

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Articles