Methysergide-Induced Valvular Heart Disease: A Report of 2 Cases

Authors

  • Ali M. Alizzi
  • Ayman H. Al-Masri
  • Mark M. Murton
  • Anand S. Dixit
  • Jonathan M. Hemli
  • Michael Challis
  • Tuck Yong
  • Michael R. Nicholson

DOI:

https://doi.org/10.1532/HSF98.20061047

Abstract

Methysergide is a serotonin antagonist and is used as a long-term prophylactic treatment for migraine. Although many patients experience adequate control of migraine episodes, methysergide has been reported to cause retroperi-toneal and pleuropulmonary fibrosis. Cardiovascular side effects mainly in the form of valvular fibrosis have been less recognized. We report 2 cases of methysergide-related mitral valve fibrosis.

References

Bana DS, MacNeal, PS, LeCompte PM, Shah Y, Graham JR. 1974. Cardiac murmurs and endocardial fibrosis associated with methysergide therapy. Am Heart J 88: 640-55.nGraham JR. 1964. Methysergide for prevention of headaches. N Eng J Med 270: 67-72.nMason JW, Billingham ME, Friedman JP. 1977. Methysergide induced heart disease. A case of multivalvular and myocardial fibrosis. Circulation 56: 889-90.nMisch KA. 1974. Development of heart valve lesions during methysergide therapy. British Medical Journal 2: 365-6.nPritchett AM, Morrison JF, Edwards WD, Schaff HV, Connolly HM, Espinosa RE. 2002. Valvular heart disease in patients taking pergolide. Mayo Clin Proc 77: 1280-6.nRedfield MM, Nicholson WJ, Edwards WD, Tajik AJ. 1992. Valve disease associated with ergot alkaloid use: echocardiographic and pathologic correlations. Ann Intern Med117:50-2.n

Published

2006-07-28

How to Cite

Alizzi, A. M., Al-Masri, A. H., Murton, M. M., Dixit, A. S., Hemli, J. M., Challis, M., Yong, T., & Nicholson, M. R. (2006). Methysergide-Induced Valvular Heart Disease: A Report of 2 Cases. The Heart Surgery Forum, 9(5), E792-E793. https://doi.org/10.1532/HSF98.20061047

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