Methysergide-Induced Valvular Heart Disease: A Report of 2 Cases


  • Ali M. Alizzi
  • Ayman H. Al-Masri
  • Mark M. Murton
  • Anand S. Dixit
  • Jonathan M. Hemli
  • Michael Challis
  • Tuck Yong
  • Michael R. Nicholson



Methysergide is a serotonin antagonist and is used as a long-term prophylactic treatment for migraine. Although many patients experience adequate control of migraine episodes, methysergide has been reported to cause retroperi-toneal and pleuropulmonary fibrosis. Cardiovascular side effects mainly in the form of valvular fibrosis have been less recognized. We report 2 cases of methysergide-related mitral valve fibrosis.


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How to Cite

Alizzi, A. M., Al-Masri, A. H., Murton, M. M., Dixit, A. S., Hemli, J. M., Challis, M., Yong, T., & Nicholson, M. R. (2006). Methysergide-Induced Valvular Heart Disease: A Report of 2 Cases. The Heart Surgery Forum, 9(5), E792-E793.