Systems Biology Approaches-based Biomarkers Discovery for Acute Aortic Dissection

  • Qiang Huang Department of Cardiovascular Surgery, Qingdao Municipal Hospital, Qingdao, P.R., China
  • Yongqiang Ren Department of Cardiovascular Surgery, Qingdao Municipal Hospital, Qingdao, P.R., China
  • Hui Li Department of Cardiovascular Surgery, Qingdao Municipal Hospital, Qingdao, P.R., China
  • Youjin Qiao Department of Cardiovascular Surgery, Qingdao Municipal Hospital, Qingdao, P.R., China
  • Mingshan Lin Department of Cardiovascular Surgery, Qingdao Municipal Hospital, Qingdao, P.R., China


Acute aortic dissection (AAD) faces great challenges in early diagnosis and effective drug treatment. Recent developments in systems biology approaches allow high-throughput screening of novel diagnostic biomarkers and potential therapeutic targets. In this review, we summarize the currently available AAD biomarkers identified in the context of genomic, transcriptomic, proteomic, and metabolic profiles, and highlight the benefits of using a combination of these findings for a better understanding of the molecular nature of this life-threatening disease. This review also provides a reference for future studies that employ a comprehensive, multiple-level approach at the single-cell level to decipher the underlying molecular pathophysiology of AAD.


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