Impacts of a Specific Cyclooxygenase-2 Inhibitor on Pressure Overload–Induced Myocardial Hypertrophy in Rats

  • Zhixiang Xie Department of Emergency, Guangzhou Red Cross Hospital, the Fourth Affiliated Hospital of Jinan University, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China
  • Shuyin Wang Department of Emergency, Women and Children Medical Center, Guangzhou, Guangdong, China
  • Zijing Liang Department of Emergency, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
  • Liangbo Zeng
  • Rongde Lai Department of Emergency, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
  • Zheng Ye Department of Emergency, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
  • Pinhu Liao Youjiang Medical University for Nationalities, Baise, Guangxi, China

Abstract

Objective: The aim of this study was to observe the impacts of the specific cyclooxygenase-2 inhibitor celecoxib on cardiac structures, functions, and inflammatory factors during the process of pressure overload–induced
myocardial hypertrophy.

Methods: Twenty-four male Sprague Dawley rats were randomly divided into 3 groups: the sham operation group, the surgery group, and the celecoxib group. The model was established according to the abdominal aortic
coarctation method.

Results: At 16 weeks, rats in the celecoxib group were fed a celecoxib-mixed diet (10 mg/kg) for 8 consecutive weeks. At week 24 after model establishment, the cardiac structures and functions were observed; changes in the levels of tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, prostaglandin E2 (PGE2), C-reactive protein (CRP), and uric acid (UA) were detected; and the contents of Smad1/2/3 proteins (Smad1, Smad2, and Smad3)  were determined. Left ventricular mass index, the heart weight/body weight ratio, and TNF-α, TGF-β, PGE2, CRP, and UA levels of the celecoxib group were all significantly decreased relative to those of the surgery group (P < .05); moreover, the cardiac functions were significantly improved compared to those of the surgery group (P < .05).

Conclusions: These results show that inflammatory factors are involved in the myocardial hypertrophy process and that celecoxib may reverse myocardial hypertrophy through a variety of pathways.

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Published
2019-10-09
How to Cite
Xie, Z., Wang, S., Liang, Z., Zeng, L., Lai, R., Ye, Z., & Liao, P. (2019). Impacts of a Specific Cyclooxygenase-2 Inhibitor on Pressure Overload–Induced Myocardial Hypertrophy in Rats. The Heart Surgery Forum, 22(6), E432-E437. https://doi.org/10.1532/hsf.1971
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Articles