Reconstruction of the Architecture of Ventricular Myocardial Fibers in Ex Vivo Human Hearts

Authors

  • Changqing Gao
  • Kun Lu
  • Weihua Ye
  • Libing Li
  • Liuquan Cheng

DOI:

https://doi.org/10.1532/HSF98.20091051

Abstract

Background: The 3-dimensional arrangement of the ventricular mass has been controversial. The aim of the present study was to investigate the macroarchitecture of ventricular myocardial fibers and to analyze whether it is consistent with the helical ventricular myocardial band (HVMB) hypothesis.

Methods: Eight excised human hearts were scanned by diffusion tensor magnetic resonance imaging (DT-MRI). Fiber tracking was then used with the DT-MRI data to reconstruct and visualize the positions of the myocardial fibers to reveal the architecture of ventricular myocardial fibers.

Results: The left ventricular myocardial fibers were found to consist of 2 crossed populations that were approximately normal from the epicardium to the endocardium in the tangent plane. The myocardial fibers in the middle of the myocardium had a smooth, linear angular rotation. The ventricular myocardial fibers maintained complete continuity and specific orientations that corresponded to the HVMB structure.

Conclusions: The architecture of the ventricular myocardial fibers in the human heart conforms to the HVMB structural hypothesis.

References

Anderson RH, Ho SY, Redmann K, Sanchez-Quintana D, Lunkenheimer PP. 2005. The anatomical arrangement of the myocardial cells making up the ventricular mass. Eur J Cardiothorac Surg 28:517-25.nAshikaga H, Criscione JC, Omens JH, et al. 2004. Transmural left ventricular mechanics underlying torsional recoil during relaxation. Am J Physiol Heart Circ Physiol 286:H640-7.nBuckberg GD, Castellá M, Gharib M, Saleh S. Active myocyte shortening during the ‘isovolumetric relaxation’ phase of diastole is responsible for ventricular suction: ‘systolic ventricular filling’ Eur J Cardiothorac Surg 2006;29(suppl 1):98-106.nBuckberg GD, Mahajan A, Jung B, Markl M, Hennig J, Ballester-Rodes M. 2006. MRI myocardial motion and fiber tracking: a confirmation of knowledge from different imaging modalities. Eur J Cardiothorac Surg 29(suppl 1):S165-77.nDokos S, Smaill BH, Young AA, LeGrice IJ. 2002. Shear properties of passive ventricular myocardium. Am J Physiol Heart Circ Physiol 283:H2650-9.nGao C, Ye WH, Li LB, et al. 2009. Investigation on the structure of ventricular mass using magnetic resonance diffusion tensor imaging. Heart Surgery Forum 12:E85-9.nGao C, Zhang T, Li LB. 2006. Empirical study of the anatomic structure of ventricular myocardial band. Chin J Thorac Cardiovasc Surg 22:410-2.nGeerts L, Bovendeerd P, Nicolay K, Arts T. 2002. Characterization of the normal cardiac myofiber field in goat measured with MR-diffusion tensor imaging. Am J Physiol Heart Circ Physiol 283:H139-45.nGilbert SH, Benson AP, Li P, Holden AV. 2007. Regional localisation of left ventricular sheet structure: integration with current models of cardiac fibre, sheet and band structure. Eur J Cardiothorac Surg 32:231-49.nHarrington KB, Rodriguez F, Cheng A, et al. 2005. Direct measurement of transmural laminar architecture in the anterolateral wall of the ovine left ventricle: new implications for wall thickening mechanics. Am J Physiol Heart Circ Physiol 288:H1324-30.nHelm PA, Tseng HJ, Younes L, McVeigh ER, Winslow RL. 2005. Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure. Magn Reson Med 54:850-9.nHsu EW, Muzikant AL, Matulevicius SA, Penland RC, Henriquez CS. 1998. Magnetic resonance myocardial fiber-orientation mapping with direct histological correlation. Am J Physiol 274:1627-34.nJouk PS, Usson Y, Michalowicz G, Grossi L. 2000. Three-dimensional cartography of the pattern of the myofibres in the second trimester fetal human heart. Anat Embryol 202:103-18.nLeGrice IJ, Smaill BH, Chai LZ, Edgar SG, Gavin JB, Hunter PJ. 1995. Laminar structure of the heart: ventricular myocyte arrangement and connective tissue architecture in the dog. Am J Physiol 269:H571-82.nRohmer D, Sitek A, Gullberg GT. 2007. Reconstruction and visualization of fiber and laminar structure in the normal human heart from ex vivo diffusion tensor magnetic resonance imaging (DTMRI) data. Invest Radiol 42:777-89.nScollan DF, Holmes A, Winslow R, Forder J. 1998. Histological validation of myocardial microstructure obtained from diffusion tensor magnetic resonance imaging. Am J Physiol 275:H2308-18.nTorrent-Guasp F, Ballester M, Buckberg GD, et al. 2001. Spatial orientation of the ventricular muscle band: physiologic contribution and surgical implications. J Thorac Cardiovasc Surg 122:389-92.nTorrent-Guasp F, Kocica MJ, Corno A, et al. 2004. Systolic ventricular filling. Eur J Cardiothorac Surg 25:376-86.nTorrent-Guasp F, Kocica MJ, Corno AF, et al. 2005. Towards new understanding of the heart structure and function. Eur J Cardiothorac Surg 27:191-201.n

Published

2009-08-14

How to Cite

Gao, C., Lu, K., Ye, W., Li, L., & Cheng, L. (2009). Reconstruction of the Architecture of Ventricular Myocardial Fibers in Ex Vivo Human Hearts. The Heart Surgery Forum, 12(4), E225-E229. https://doi.org/10.1532/HSF98.20091051

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