Impact of Genetic Defects on Coronary Atherosclerosis among Turkish Cypriots


  • Cenk Conkbayir Department of Cardiology, Near East University, Nicosia, Cyprus
  • Rezan Fahrioglu Yamaci Department of Molecular Biology and Genetics, Bogazici University, NDAL, Istanbul, Turkey
  • Pinar Gencer Department of Molecular Biology and Genetics, Bogazici University, NDAL, Istanbul, Turkey
  • Burc Barin Department of Biomedical Engineering, Near East University, Nicosia, Cyprus
  • Genco Yucel Department of Cardiology, American Hospital, Istanbul, Turkey
  • Cenk Eray Yildiz Institute of Cardiology, Istanbul University, Istanbul, Turkey
  • Murat Ugurlucan Department of Cardiovascular Surgery, Istanbul University Istanbul Medical Faculty, Istanbul, Turkey
  • A Nazli Basak Department of Molecular Biology and Genetics, Bogazici University, NDAL, Istanbul, Turkey



Background: The distribution of gene variants in the Turkish Cypriot population with coronary artery disease has not been investigated. In this study, we sought to research different genetic variants in the susceptibility to coronary artery disease and to identify possible associations between various clinical parameters and the genes involved in blood coagulation as well as glucose and lipid metabolism among the Turkish Cypriots and compared the results with the respective Turkish patients from Turkey. 

Methods: A total of 187 individuals with coronary artery disease, namely 87 Turkish Cypriot individuals from Northern Cyprus, and 100 Turkish patients from Turkey, were investigated. The presence of CAD was documented with coronary angiography. The genetic susceptibility to coronary artery disease in the cohorts was studied using the variants FV Leiden (G1691A), Factor V R2 mutation (FVR2)(H1299R), PTH (G20210A), FXIII (V34L), β-Fibrinogen (-455 G>A), PAI-1 (4G/5G), HPA1 (a/b), MTHFR [C677T] and [A1298C], ACE (I/D), Apo B (R3500Q), and Apo E, in addition to the well-known risk factors associated with coronary artery disease.

Results: Age, male sex, diabetes mellitus, hyperlipidemia, triglycerides, HDL, and triglyceride/HDL ratio were significantly associated with (P < .05); LDL (P = .05) and total cholesterol (P = .08) was marginally associated with coronary artery disease in the Turkish Cypriot population. The mutations in the MTHFR [C677T] gene variant were marginally higher in the Turkish Cypriot cohort when compared with the Turkish patients from Turkey (P = .06). No significant direct association of any of the gene variants with coronary artery disease in the Turkish Cypriot cohort could be defined. Several of the genetic variants were associated indirectly with the risk factors for coronary artery disease in Turkish Cypriots. MTHFR [A1298C] was found to be marginally associated with low HDL cholesterol (P = .08). MTHFR [C677] wild-type allele was significantly associated with a decreased rate of high LDL cholesterol (P < .05). The HPA-1 a/b variant was significantly associated with an increased rate of high total cholesterol levels (P < .05). 

Conclusion: Turkish Cypriot patients with coronary artery disease may be more affected by secondary factors, such as diabetes, hypertension, obesity, and sedentary life style when compared with genetic factors, which may be responsible for coronary artery disease.


Author Biography

Rezan Fahrioglu Yamaci, Department of Molecular Biology and Genetics, Bogazici University, NDAL, Istanbul, Turkey



Acarturk E, Attila G, Bozkurt A, Akpinar O, Matyar S, Seydaoglu G. 2005. Insertion/deletion polymorphism of the angiotensin converting enzyme gene in coronary artery disease in southern Turkey. J Biochem Mol Biol 38:486-90.

Agirbasli D, Agirbasli M, Williams SM, Phillips JA 3rd. 2006. Interaction among 5,10 methylenetetrahydrofolate reductase, plasminogen activator inhibitor and endothelial nitric oxide synthase gene polymorphisms predicts the severity of coronary artery disease in Turkish patients. Coron Artery Dis 17:413-7.

Akar N, Aras O, Omürlü K, Cin S. 1998. Deletion polymorphism at the angiotensin-converting enzyme gene in Turkish patients with coronary artery disease. Scand J Clin Lab Invest 58:491-5.

Araz M, Aynacioglu S, Okan V, Akdemir I, Aktaran S. 2002. Angiotensin-converting enzyme gene polymorphism and coronary heart disease in Turkish type 2 diabetic patients. Acta Cardiol 57:265-9.

Conkbayir C, Ayça B, Ökçün EB. 2015. Lipid variables related to the extent and severity of coronary artery disease in non-diabetic Turkish Cypriots. Iran J Public Health 44:1196-203.

Gardemann A, Arsic T, Katz N, Tillmanns H, Hehrlein FW, Haberbosch W. 1999. The factor II G20210A and factor V G1691A gene transitions and coronary heart disease. Thromb Haemost 81: 208-13.

Isbir T, Yilmaz H, Ağaçhan B, Aydin M, Isbir CS. 1999. Association between angiotensin-converting enzyme gene polymorphism and coronary artery disease. IUBMB Life 48:205-7.

Kotaska K, Kolarova J, Kotrcova K, Cepova J, Prusa R. 2012. Correlation between common genetic variants and risk factors associated with prediction of cardiovascular diseases in dyslipidemic patients. Genet Test Mol Biomarkers 16:210-4.

Lunegova OS, Kerimkulova AS, Turdakmatov NB, et al. 2011. Association of C677T gene polymorphism of methylenetetrahydrofolate reductase with insulin resistance among Kirghizes. Kardiologiia 51:58-62.

Onrat ST, Akci O, Söylemez Z, Onrat E, Avşar A. 2012. Prevalence of myocardial infarction polymorphisms in Afyonkarahisar, Western Turkey. Mol Biol Rep 39: 9257-64.

Peden JF, Farrall M. 2011. Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour. Hum Mol Genet 20:R198-205.

Pfohl M, Koch M, Prescod S, Haase KK, Häring HU, Karsch KR. 1999. Angiotensin I-converting enzyme gene polymorphism, coronary artery disease and myocardial infarction. An angiographically controlled study. Eur Heart J 20:1318-25.

Russo C, Girelli D, Olivieri O, et al. 2001. G20210A prothrombin gene polymorphism and prothrombin activity in subjects with or without angiographically documented coronary artery disease. Circulation, 103:2436-40.

Taymaz H, Erarslan S, Oner ET, Alkan T, Ağirbaşli M, Kirdar B. 2007. Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population. Thromb Res 119:55-62.

Ünal B, Sözmen K, Uçku R, et al. 2013. High prevalence of cardiovascular risk factors in a western urban Turkish population: a community-based study. Anadolu Krdiyol Derg 1:9-17.

Var A, Utük O, Akçali S, Sanlidağ T, Uyanik BS, Dinç G. 2009. Impact of hemostatic gene single point mutations in patients with non-diabetic coronary artery disease. Mol Biol Rep 36:2235-43.

von Depka M, Nowak-Göttl U, Eisert R. 2000. Increased lipoprotein (a) levels as an independent risk factor for venous thromboembolism. Blood 96:3364-8.

Wachira JK, Stys TP. 2013. Cardiovascular disease and bridging the diagnostic gap. S D Med 66:366-9.

Zdravkovic S, Wienke A, Pedersen NL, Marenberg ME, Yashin AI, de Faire U. 2004. Genetic influences on CHD-death and the impact of known risk factors: comparison of two frailty models. Behav Genet 34:585-92.

Zintzaras E, Raman G, Kitsios G, Lau J. 2008. Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. Arch Intern Med 168:1077-89.



How to Cite

Conkbayir, C., Fahrioglu Yamaci, R., Gencer, P., Barin, B., Yucel, G., Yildiz, C. E., Ugurlucan, M., & Basak, A. N. (2017). Impact of Genetic Defects on Coronary Atherosclerosis among Turkish Cypriots. The Heart Surgery Forum, 20(5), E223-E229.




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