Evolution of Cardiac Biomodels from Computational to Therapeutics

Authors

  • Alwin Kumar Rathinam Heartstrings Research & Innovation and 2Cardiovascular and Thoracic Surgery Unit, Department of Surgery, University of Malaya, Kuala Lumpur
  • Raja Amin Raja Mokhtar Heartstrings Research & Innovation and 2Cardiovascular and Thoracic Surgery Unit, Department of Surgery, University of Malaya, Kuala Lumpur

DOI:

https://doi.org/10.1532/hsf.1410

Abstract

Biomodeling the human anatomy in exact structure and size is an exciting field of medical science. Utilizing medical data from various medical imaging topography, the data of an anatomical structure can be extracted and converted into a three-dimensional virtual biomodel; thereafter a physical biomodel can be generated utilizing rapid prototyping machines. Here, we have reviewed the utilization of this technology and have provided some guidelines to develop biomodels of cardiac structures. Cardiac biomodels provide insights for cardiothoracic surgeons, cardiologists, and patients alike. Additionally, the technology may have future usability for tissue engineering, robotic surgery, or routine hospital usage as a diagnostic and therapeutic tool for cardiovascular diseases (CVD). Given the broad areas of application of cardiac biomodels, attention should be given to further research and development of their potential.

Author Biographies

Alwin Kumar Rathinam, Heartstrings Research & Innovation and 2Cardiovascular and Thoracic Surgery Unit, Department of Surgery, University of Malaya, Kuala Lumpur

Lead Application Developer
and Software Architect
Heartstrings Research & Innovation

University of Malaya
Kuala Lumpur, Malaysia

 

Raja Amin Raja Mokhtar, Heartstrings Research & Innovation and 2Cardiovascular and Thoracic Surgery Unit, Department of Surgery, University of Malaya, Kuala Lumpur

Professor,

Head & Senior Consultant Cardiovascular & Thoracic Surgeon Cardiovascular & Thoracic Surgery Unit Department of Surgery Faculty of Medicine University of Malaya
Kuala Lumpur, Malaysia

References

Aiken A, Colella P, Gay D, et al. 1998. Titanium: A high-performance Java dialect. Concurrency: Pract Ex 10:11-13.

Argall BD, Chernova S, Veloso M, Browning B. 2009. A survey of robot learning from demonstration. Robot Auton Syst 57:469-83.

Armillotta A, Bonhoeffer P, Dubini G, et al. 2007. Use of rapid prototyping models in the planning of percutaneous pulmonary valved stent implantation. Proc Inst Mech Eng H 221:407-16.

Beaver T, Lee W. 2015. Thoracic Endovascular Aortic Repair [Updated Jan 12 2015; Cited 6 Jun 2015]. Available from http://emedicine.medscape.com/article/1384667-overview.

Bhatnagar P, Wickramasinghe K, Williams J, Rayner M, Townsend N. 2015. The epidemiology of cardiovascular disease in the UK 2014. Heart 101:1182-9.

Biglino G, Capelli C, Wray J, et al. 2015. 3D-manufactured patient-specific models of congenital heart defects for communication in clinical practice: feasibility and acceptability. BMJ Open 5:e007165.

Binder TM, Moertl D, Mundigler G, et al. 2000. Stereolithographic biomodeling to create tangible hard copies of cardiac structures from echocardiographic data: in vitro and in vivo validation. J Am Coll Cardiol 35:230-7.

Bruyere F, Leroux C, Brunereau L, Lermusiaux P. 2008. Rapid prototyping model for percutaneous nephrolithotomy training. Journal of Endourol 22:91-6.

BWH. [Internet] 3D Slicer [n.d., Cited 21 July 2015]. Available online at http://www.slicer.org

Canstein C, Cachot P, Faust A, et al. 2008. 3D MR flow analysis in realistic rapid-prototyping model systems of the thoracic aorta: comparison with in vivo data and computational fluid dynamics in identical vessel geometries. Magn Reson Med 59:535-46.

Cardiac Biomodels [Internet]. Cardiac Biomodel page. Available from http://cardiac.researchbiomodels.com

Cavanaugh PK, Mounts T, Vaccaro AR. 2015. Use of 3-dimensional printing in spine care. Contemporary Spine Surg 16:1-5.

Chang CC. 2004. Rapid prototyping fabricated by UV resin spray nozzles. Rapid Prototyping J 10:136-45.

Chang CC. 2004. Direct slicing and G-code contour for rapid prototyping machine of UV resin spray using PowerSOLUTION macro commands. Int J Adv Manuf Tech 23:358-65.

Chapron J, Hosny H, Torii R, Sedky Y, Donya M, Yacoub MH. 2013. Lessons from patient-specific 3D models of the cardiac chambers after the Mustard operation. Global Cardiol Sci Pr 4:409.

Costello JP, Olivieri LJ, Krieger A, et al. 2014. Utilizing three-dimensional printing technology to assess the feasibility of high-fidelity synthetic ventricular septal defect models for simulation in medical education. World J Pediatric Congenital Heart Surg 5:421-6.

Costello JP, Olivieri LJ, Su L, et al. 2015. Incorporating three-dimensional printing into a simulation-based congenital heart disease and critical care training curriculum for resident physicians. Congenital Heart Dis 10:185-90.

Dankowski R, Baszko A, Sutherland M, et al. 2014. 3D heart model printing for preparation of percutaneous structural interventions: description of the technology and case report. Kardiol Pol 72:546-51.

Díaz-Lantada A, Mosquera A, Endrino JL, Lafont P. 2010. Design and rapid prototyping of DLC coated fractal surfaces for tissue engineering applications. In J Phys 252:012003.

D’Urso PS, Barker TM, Earwaker WJ, et al. 1999. Stereolithographic biomodelling in cranio-maxillofacial surgery: a prospective trial. J Cranio Maxill Surg 27:30-7.

Engstrand T, Kihlström L, Neovius E, et al. 2014. Development of a bioactive implant for repair and potential healing of cranial defects: Technical note. J Neurosurgery 120:273-7.

Esses SJ, Berman P, Bloom AI, Sosna J. 2007. Clinical applications of physical 3D models derived from MDCT data and created by rapid prototyping. Am J Roentgenology 196:W683-8.

Fantini M, de Crescenzio F, Persiani F, Benazzi S, Gruppioni G. 2008. 3D restitution restoration and prototyping of a medieval damaged skull. Rapid Prototyping J 14:318-24.

Fedorovich NE, Alblas J, Hennink WE, Öner FC, Dhert WJ. 2013. Organ printing: the future of bone regeneration? Trends Biotechnol 29:601-6.

Gaebel R, Ma N, Liu J, et al. 2011. Patterning human stem cells and endothelial cells with laser printing for cardiac regeneration. Biomaterials 32:9218-30.

Gaetani R, Doevendans PA, Metz CH, et al. 2012. Cardiac tissue engineering using tissue printing technology and human cardiac progenitor cells. Biomaterials 33:1782-90.

Gerstle TL, Ibrahim AM, Kim PS, Lee BT, Lin SJ. 2014. A plastic surgery application in evolution: three-dimensional printing. Plast Reconstr Surg 133:446-51.

Griffith BE, Luo X, McQueen DM, Peskin CS. 2009. Simulating the fluid dynamics of natural and prosthetic heart valves using the immersed boundary method. Int J App Mech 1:137-77.

Horvath J. 2014. A brief history of 3D printing in mastering 3D printing. Apress, 3-10.

Hurlock GS, Higashino H, Mochizuki T. 2009. History of cardiac computed tomography: single to 320-detector row multislice computed tomography. The Int Cardiovas Imaging 25:31-42.

Ikegami T, Maehara Y. 2013. Transplantation: 3D printing of the liver in living donor liver transplantation. Nat Rev Gastroent Hepatol 10:697-8.

Jones BA, Krueger S, Howell D, Meinecke B, Dunn S. 2005. Robotic mitral valve repair: a community hospital experience. Texas Heart I J 32:143.

Kalejs M, von Segesser LK. 2009. Rapid prototyping of compliant human aortic roots for assessment of valved stents Interactive cardiovascular and thoracic surgery. 8:182-6.

Karbaschi K. 2014. A new method for biomodelling and rapid prototyping of human’s hard tissues as substituting prostheses. Int J Adv Design Manuf Tech 6:33-42.

Kelley DJ, Farhoud M, Meyerand ME, et al. 2007. Creating physical 3D stereolithograph models of brain and skull. PLoS One 2:e1119.

Kim MS, Hansgen AR, Wink O, Quaife RA, Carroll JD. 2008. Rapid prototyping: a new tool in understanding and treating structural heart disease. Circulation 117:2388-94.

Knox K, Kerber CW, Singel SA, Bailey MJ, Imbesi SG. 2005. Rapid prototyping to create vascular replicas from CT scan data: making tools to teach rehearse and choose treatment strategies. Catheter Cardiov Inte 65:47-53.

Mahmood F, Owais K, Taylor C, et al. 2015. Three-dimensional printing of mitral valve using echocardiographic data. JACC: Cardiovasc Imaging 8:227-9.

Maragiannis D, Jackson MS, Igo SR, Chang SM, Zoghbi WA, Little SH. 2014. Functional 3D Printed Patient-Specific Modeling of Severe Aortic Stenosis. J Am Coll of Cardio 64:1066-8.

Miller JM, Rochitte CE, Dewey M, et al. 2008. Diagnostic performance of coronary angiography by 64-row CT. New Engl J Med 359:2324-36.

Mironov V, Boland T, Trusk T, Forgacs G, Markwald RR. 2003. Organ printing: computer-aided jet-based 3D tissue engineering. Trends Biotechnol 21:157-61.

Olivieri LJ, Krieger A, Loke YH, Nath DS, Kim PC, Sable CA. 2015. Three-dimensional printing of intracardiac defects from three-dimensional echocardiographic images: feasibility and relative accuracy. J Am Soc Echocardiog 28:392-7.

O’Neill B, Wang DD, Pantelic M, Song T, et al. 2015. Transcatheter caval valve implantation using multimodality imaging: roles of TEE CT and 3D printing. JACC: Cardiovasc Imag 8:221-5.

Pelletier B, Spiliopoulos S, Finocchiaro T, Graef F, Kuipers K, Laumen M. 2014. System overview of the fully implantable destination therapy—ReinHeart-total artificial heart. Eur J Cardio-Thorac 46:935-6.

Poldermans D, Bax JJ, Boersma E, et al. 2009. Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non- cardiac surgery. Eur Heart J 30:2769-2812.

Rathinam AK, Mokhtar BR, Amin R, et al. 2013. Biomodelling methods employed to reconstruct three dimension anatomically accurate substructures of the human cardiac anatomy. In: Artificial Intelligence Modelling and Simulation (AIMS) 2013, 87-91.

Riesenkampff E, Rietdorf U, Wolf I, et al. 2008. The practical clinical value of three-dimensional models of complex congenitally malformed hearts. J Thorac Cardiov Surg 138:571-80.

Roque WL. 2013. Trabecular Bone Modeling with Support of 3D Printing of Physical Replicas Low-Cost 3D Printing. 133.

Rosset A, Spadola L, Ratib O. 2004. OsiriX: an open-source software for navigating in multidimensional DICOM images. J Digit Imaging 17:205-16.

Sailer HF, Haers PE, Zollikofer CP, Warnke T, Carls FR, Stucki P. 1998. The value of stereolithographic models for preoperative diagnosis of craniofacial deformities and planning of surgical corrections. Int J Oral Maxillofac Surg 27:327-33.

Samuel BP, Pinto C, Pietila T, Vettukattil JJ. 2015. Ultrasound-derived three-dimensional printing in congenital heart disease. J Digit Imaging 28:459-61.

Sannomiya EK, Silva JVL, Brito AA, Saez DM, Angelieri F, da Silva Dalben G. 2008. Surgical planning for resection of an ameloblastoma and reconstruction of the mandible using a selective laser sintering 3D biomodel. Oral Surg Oral Med O 106:e36-40.

Schmauss D, Gerber N, Sodian R. 2013. Three-dimensional printing of models for surgical planning in patients with primary cardiac tumors. J Thorac Cardiovasc Surg 145:1407-8.

Schmauss D, Haeberle S, Hagl C, Sodian R. 2015. Three-dimensional printing in cardiac surgery and interventional cardiology: a single-centre experience. European J Cardiothorac Surg 47:1044-52.

Schubert C, van Langeveld MC, Donoso LA. 2013. Innovations in 3D printing: a 3D overview from optics to organs. Brit J Ophthalmol 98:159-61.

Scruggs SB, Watson K, Su AI, et al. 2015. Harnessing the heart of big data. Circulation 116:1115-19.

Shiraishi I, Kajiyama Y, Yamagishi M, Hamaoka K. 2006. Stereolithographic biomodeling of congenital heart disease by multislice computed tomography imaging. Circulation 113: e733-4.

Shiraishi I, Kurosaki K, Kanzaki S, Ichikawa H. 2014. Development of super flexible replica of congenital heart disease with stereolithography 3D printing for simulation surgery and medical education. J Card Fail 20:S180-1.

Silva JVL, Gouveia MF, Santa Barbara A, Meurer E, Zavaglia CA. 2004. Rapid prototyping applications in the treatment of craniomaxillofacial deformities. Utilization of Bioceramics In Key Eng Mat 254:687-90.

Siminiak T, Dankowski R, Baszko A, et al. 2013. Percutaneous direct mitral annuloplasty using the Mitralign Bident system: description of the method and a case report. Kardiol Pol 71:1287-92.

Slagt C, Beute J, Hoeksema M, Malagon I, Mulder JWR, Groeneveld JA. 2010. Cardiac output derived from arterial pressure waveform analysis without calibration vs. thermodilution in septic shock: evolving accuracy of software versions. Eur J Anaesthesiol (EJA). 27(6):550-4.

Sodian R, Weber S, Markert M, et al. 2008. Pediatric cardiac transplantation: three-dimensional printing of anatomic models for surgical planning of heart transplantation in patients with univentricular heart. J Thorac Cardiov Surgery 136:1098-9.

Starly B, Fang Z, Sun W, Shokoufandeh A, Regli W. 2005. Three-dimensional reconstruction for medical-CAD modeling. Comput Aided Design and Appl 2:431-8.

Stewart N, Lock G, Hopcraft A, Kanesarajah J, Coucher J. 2014. Stereoscopy in diagnostic radiology and procedure planning: Does stereoscopic assessment of volume-rendered CT angiograms lead to more accurate characterisation of cerebral aneurysms compared with traditional monoscopic viewing? J Medical Imag Radiat Oncol 58:172-82.

Sulaiman A, Boussel L, Taconnet F, et al. 2008. In vitro non-rigid life-size model of aortic arch aneurysm for endovascular prosthesis assessment. Eur J Cardiothor Surg 33:53-7.

Trayanova N. 2014. Custom Cardiology: A Virtual Heart for Every Patient [Updated Oct 28 2014; Cited July 6 2015]. Available online at http://spectrum.ieee.org/biomedical/imaging/custom-cardiology-a-virtual-heart-for-every-patient

Ukwatta E, Rajchl M, White J, Pashakhanloo F, Herzka DA, McVeigh E. 2015. Image-based reconstruction of 3D myocardial infarct geometry for patient specific applications. In: SPIE Medical Imaging. International Society for Optics and Photonics 94132W-94132W.

Uma Maheshwaraa N, Arumaikkannu G, Gowri S. 2008. Three-

dimensional reconstruction and rapid prototyping of femur bone using multiple digital X-rays. J Med Eng Tech 32:30-9.

Valverde I, Gomez G, Gonzalez A, et al. 2015. Three-dimensional patient-specific cardiac model for surgical planning in Nikaidoh procedure. Cardiol Young 25:698-704.

Valverde I, Gomez G, Coserria JF, et al. 2015. 3D printed models for planning endovascular stenting in transverse aortic arch hypoplasia. Catheter Cardio Inte 85:1006-12.

van Assen HC, Danilouchkine MG, Behloul F, et al. 2004. Cardiac LV segmentation using a 3D active shape model driven by fuzzy inference. In: Medical Image Computing and Computer-Assisted Intervention-MICCAI 2003. Springer Berlin Heidelberg, p. 533-40.

Verday J. 2015. Echocardiography and three-dimensional printing: sound ideas to touch a heart. J Am Soc Echocardiog 28:398-403.

Vivian L, Naidu C, Hunter C, Lawrenson J, Comitis G, Argent A. 2014. A qualitative study of cardiac surgery and preoperative care at the Red Cross War Memorial Children’s Hospital Cape Town, South Africa. Pediatr Crit Care Med 15(4_suppl):22.

Published

2016-08-23

How to Cite

Rathinam, A. K., & Mokhtar, R. A. R. (2016). Evolution of Cardiac Biomodels from Computational to Therapeutics. The Heart Surgery Forum, 19(4), E208-E215. https://doi.org/10.1532/hsf.1410

Issue

Section

Articles

Most read articles by the same author(s)