The Best Anticoagulation Therapy in Multiple-Trauma Patients with Mechanical Heart Valves: Evaluation of Latest Guidelines and Studies


  • Aliasghar Moeinipour Atherosclerosis Prevention Research Center, Mashhad University of Medical Sciences, Imam Reza Hospital, Mashhad
  • Ahmadreza Zarifian Mashhad University of Medical Sciences, Imam Reza Hospital, Mashhad
  • Mohammad Sobhan Sheikh Andalibi Mashhad University of Medical Sciences, Imam Reza Hospital, Mashhad
  • Alireza Sepehri Shamloo Mashhad University of Medical Sciences, Imam Reza Hospital, Mashhad
  • Ali Ahmadabadi Mashhad University of Medical Sciences, Imam Reza Hospital, Mashhad
  • Ahmad Amouzeshi Birjand University of Medical Sciences, Birjand
  • Hamid Hoseinikhah Atherosclerosis Prevention Research Center, Mashhad University of Medical Sciences, Imam Reza Hospital, Mashhad



Background: It is common practice for patients with prosthetic cardiac devices, especially heart valve prosthesis, arterial stents, defibrillators, and pacemaker devices, to use anticoagulation treatment. When these patients suffer from multiple trauma after motor vehicle accidents, the best medical management for this challenging position is mandatory. This strategy should include a rapid diagnosis of all possible multiple organ injuries, with special attention to anticoagulation therapy so as to minimize the risk of thromboembolism complication in prosthetic devices. In this review, we describe the best medical management for patients with multiple trauma who use anticoagulants after heart valve replacement.
Methods: We searched electronic databases PubMed/Medline, Scopus, Embase, and Google Scholar using the following terms: anticoagulant, warfarin, heparin, and multiple trauma. Also, similar studies suggested by the databases were included. Non-English articles were excluded from the review.
Results: For patients who use anticoagulation therapy, teamwork between cardiac surgeons, general surgeons, anesthesiologists, and cardiologists is essential. For optimal medical management, multiple consults between members of this team is mandatory for rapid diagnosis of all possible damaged organs, with special attention to the central nervous system, chest, and abdominal traumas. With this strategy, it is important to take note of anticoagulation drugs to minimize the risk of thromboembolism complications in cardiac devices.
Conclusion: The best anticoagulant agents for emergency operations in patients with multiple trauma who are using an anticoagulant after heart valve replacement are fresh frozen plasma (FFP) and prothrombin complex concentrates (PCC).

Author Biography

Aliasghar Moeinipour, Atherosclerosis Prevention Research Center, Mashhad University of Medical Sciences, Imam Reza Hospital, Mashhad

Cardiac surgery


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How to Cite

Moeinipour, A., Zarifian, A., Sheikh Andalibi, M. S., Shamloo, A. S., Ahmadabadi, A., Amouzeshi, A., & Hoseinikhah, H. (2015). The Best Anticoagulation Therapy in Multiple-Trauma Patients with Mechanical Heart Valves: Evaluation of Latest Guidelines and Studies. The Heart Surgery Forum, 18(6), E271-E274.