Randomized Trial Comparing Off-Pump to On-Pump Coronary Artery Bypass Grafting in High-Risk Patients


  • Michel Carrier
  • Louis P. Perrault
  • Hugues Jeanmart
  • Raymond Martineau
  • Raymond Cartier
  • Pierre Pagé




Objective: The subset of patients most likely to benefit from off-pump coronary artery bypass grafting (CABG) remains a controversial issue, but the technique has been proposed to decrease postoperative mortality and morbidity. The objective of this study was to compare off-pump to on-pump CABG in patients with known risk factors for mortality and morbidity.

Methods: Between October 2001 and September 2002, 65 high-risk patients were prospectively randomized to undergo off-pump or on-pump CABG. Recruited patients had at least 3 of the following criteria: age greater than 65 years, high blood pressure, diabetes, serum creatinine greater than 133 3mol/L, left ventricular ejection fraction lower than 45%, chronic pulmonary disease, unstable angina, congestive heart failure, repeat CABG, anemia, and carotid atherosclerosis. Hospital mortality and morbidity were the primary end-points of the study.

Results: Six patients (9%) crossed over from the original randomized group. Twenty-eight patients averaging 70 ± 8 years of age underwent 3 ± 1 grafts off pump, and 37 patients averaging 70 ± 6 years of age underwent 3.4 ± 1 grafts on pump. Revascularization was considered complete in 21 (75%) of off-pump patients compared to 33 (89%) of on-pump patients (P = .1). There were no hospital deaths in off-pump patients, and 2 patients (5%) undergoing on-pump CABG died early following surgery (P = .2). Two off-pump (7%) compared to 11 on-pump (30%) of patients presented composite end-points including death, neurological injury, renal failure, respiratory failure, and operative myocardial infarction after CABG (P = .02).

Conclusion: The present study suggests that off-pump CABG, when technically feasible, significantly reduces morbidity following surgery in a group of high-risk patients.


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How to Cite

Carrier, M., Perrault, L. P., Jeanmart, H., Martineau, R., Cartier, R., & Pagé, P. (2005). Randomized Trial Comparing Off-Pump to On-Pump Coronary Artery Bypass Grafting in High-Risk Patients. The Heart Surgery Forum, 6(6), E89-E92. https://doi.org/10.1532/hsf.1094