TY - JOUR AU - Inoue, Masahiro AU - McCarthy, Patrick M. AU - Popovic, Zoran B. AU - Doi, Kazuyoshi AU - Schenk, Soren AU - Nemeh, Hassan AU - Ootaki, Yoshio AU - Kopcak, Jr, Michael W. AU - Dessoffy, Raymond AU - Thomas, James D. AU - Fukamachi, Kiyotaka PY - 2005/01/04 Y2 - 2024/03/28 TI - Mitral Valve Repair without Cardiopulmonary Bypass or Atriotomy Using the Coapsys Device: Device Design and Implantation Procedure in Canine Functional Mitral Regurgitation Model JF - The Heart Surgery Forum JA - HSF VL - 7 IS - 2 SE - DO - 10.1532/HSF98.200344395 UR - https://journal.hsforum.com/index.php/HSF/article/view/609 SP - 69-73 AB - <strong>Background</strong>: Myocor developed a unique system, the<br />Coapsys annuloplasty system, to treat functional mitral<br />regurgitation (MR) without cardiopulmonary bypass (CPB).<br />This study was conducted to test the feasibility of the Coapsys<br />implantation procedure in a canine functional MR model.<br /><strong>Methods</strong>: Functional MR with heart failure was induced<br />in 9 dogs by rapid ventricular pacing (230 beats/min for<br />30 ± 4 days). The Coapsys device, which consists of anterior<br />and posterior epicardial pads connected by a subvalvular<br />chord, was then surgically implanted. Under epicardial<br />echocardiographic guidance, we placed the Coapsys device<br />across the left ventricular chamber using the delivery instrument<br />and needle assembly. We sized the Coapsys device by<br />drawing the posterior leaflet and annulus toward the anterior<br />leaflet with the sizing instrument. Final device size was<br />selected when MR was minimized or eliminated as assessed<br />by 2-dimensional color Doppler echocardiography.<br /><strong>Results</strong>: In all cases, we successfully implanted the Coapsys<br />device without CPB or atriotomy. MR was reduced an<br />average of 2 grades. No adverse events, such as hemodynamic<br />compromise or structural valve damage, were noted.<br /><strong>Conclusion</strong>: Coapsys device implantation was feasible<br />and safe on a beating canine heart. All accessory tools used<br />for device implantation were found useful. ER -