TY - JOUR AU - Wu, Chenxia AU - Lv, Zhengtian AU - Li, Xinyi AU - Zhou, Xinbing AU - Mao, Wei AU - Zhu, Min PY - 2021/03/30 Y2 - 2024/03/28 TI - Galectin-3 in Predicting Mortality of Heart Failure: A Systematic Review and Meta-Analysis JF - The Heart Surgery Forum JA - HSF VL - 24 IS - 2 SE - DO - 10.1532/hsf.3547 UR - https://journal.hsforum.com/index.php/HSF/article/view/3547 SP - E327-E332 AB - <p class="p1"><span class="s1"><strong>Background</strong>: In recent years, galectin-3, an inflammatory marker, has been demonstrated to be closely related to cardiac fibrosis and heart failure. The purpose of this systematic review and meta-analysis is to define galectin-3 in predicting mortality of heart failure.</span></p><p class="p1"><span class="s1"><strong>Methods</strong>: PubMed, Embase, and the Cochrane Library were searched. A total of 1540 studies were identified, and of these studies, 19 involving 9217 patients were included in our meta-analysis.</span></p><p class="p1"><span class="s1"><strong>Results</strong>: The diagnostic hazard ratios of galectin-3 in predicting mortality in chronic heart failure patients was 1.13 (95% CI,:1.07-1.21 ) and 2.17 (95% CI:1.27-3.08) in acute heart failure (HF) patients.</span></p><p class="p1"><span class="s1"><strong>Conclusions</strong>: Our meta-analysis shows that elevated levels of galectin-3 are associated with higher mortality in both acute and chronic heart failure patients.</span></p> ER -