TY - JOUR AU - Erdolu, Burak AU - As, Ahmet Kagan PY - 2020/07/08 Y2 - 2024/03/29 TI - C-Reactive Protein and Neutrophil to Lymphocyte Ratio Values in Predicting Inhospital Death in Patients with Stanford Type A Acute Aortic Dissection JF - The Heart Surgery Forum JA - HSF VL - 23 IS - 4 SE - DO - 10.1532/hsf.3055 UR - https://journal.hsforum.com/index.php/HSF/article/view/3055 SP - E488-E492 AB - <p class="p1"><span class="s1"><strong>Background:</strong> Aortic dissection is a cardiovascular disease with high mortality and morbidity rates. The aim of this study is to investigate the role of C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) in predicting in-hospital mortality in patients undergoing emergent surgery for Stanford type A aortic dissection.</span></p><p class="p1"><span class="s2"><strong>Methods:</strong> Patients operated for acute Stanford type A aortic dissection between January 2010 and December 2018 were included in the study. Patients without in-hospital mortality were classified as Group 1, and patients with mortality were classified as Group 2.</span></p><p class="p1"><span class="s1"><strong>Results:</strong> One-hundred-eighteen patients were involved in the study. Patient mean age was 57 ± 11.7 years, and 89 patients (75.4%) were male. Neutrophil-to-lymphocyte ratio (NLR), white blood cell (WBC), neutrophil counts, and C-reactive protein (CRP) values at the time of admission also were found to be high in Group 2 (<em>P</em> = .001, .021, &lt; .001, &lt; .001 respectively). Total perfusion times (TPt), antegrade cerebral perfusion time (ACPt), cross-clamp time (CCt), and intensive care unit (ICU) stay periods significantly were higher in the mortality group (<em>P</em> &lt; .001, &lt; .001, = .01, and &lt; .001, respectively). In receiver-operating characteristic (ROC) curve analysis, a cut-off level of 23 mg/L was determined for CRP levels that predict progression to mortality (area under the curve (AUC): 0.879, <em>P</em> &lt; .001, 75.0% sensitivity and 58.0% specificity). Similarly, a cut-off level of 8.8 was found for NLR that predicts progression to mortality (AUC: 0.835, <em>P</em> &lt; .001, 76.0% sensitivity and 61.0% specificity).</span></p><p class="p1"><span class="s1"><strong>Conclusion:</strong> As a result, we can use CRP and NLR values, which easily can be measured or calculated from blood tests to predict mortality in patients with aortic dissections, which may have serious mortal consequences.</span></p> ER -