TY - JOUR AU - Yang, Jie AU - Wang, Qing AU - Wang, Suyu AU - Zhang, Yufeng AU - Wang, Zhinong PY - 2019/03/08 Y2 - 2024/03/28 TI - Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature JF - The Heart Surgery Forum JA - HSF VL - 22 IS - 2 SE - DO - 10.1532/hsf.2141 UR - https://journal.hsforum.com/index.php/HSF/article/view/2141 SP - E119-E123 AB - <p class="p1"><span class="s1"><strong>Introduction:</strong> Drug fever is a febrile reaction caused by initiation of one drug or varieties of drugs and often disappears after cessation of the drug(s). Clinically, drug fever is frequently induced by antibiotics, anticonvulsants, and antineoplastics. There are few previous reports about drug fever caused by imipenem/cilastatin.</span></p><p class="p1"><span class="s1"><strong>Case Presentation: </strong>Here, we described a 66-year-old man undergoing the Ivor Lewis esophagectomy for esophageal carcinoma, who developed drug fever. The patient had a high temperature with shivering after administration of imipenem/cilastatin for 7 days. Furthermore, his temperature came down after discontinuing imipenem/cilastatin and receiving steroids. Body temperature increased rapidly <br> 4 hours after intravenous readministration of imipenem/cilastatin and rapidly decreased to normal after discontinuing imipenem/cilastatin and administering steroids.</span></p><p class="p1"><span class="s1"><strong>Conclusion: </strong>Thorough history, blood tests, physical examination, and computed tomography (CT) did not reveal any evidence of fever. Drug fever caused by imipenem/cilastatin was considered. We also present a review of relevant literature and provide a point of reference for the clinical diagnosis and therapy of patients with drug fever.</span></p> ER -