@article{Inoue_McCarthy_Popovic_Doi_Schenk_Nemeh_Ootaki_Kopcak, Jr_Dessoffy_Thomas_Fukamachi_2005, title={Mitral Valve Repair without Cardiopulmonary Bypass or Atriotomy Using the Coapsys Device: Device Design and Implantation Procedure in Canine Functional Mitral Regurgitation Model}, volume={7}, url={https://journal.hsforum.com/index.php/HSF/article/view/609}, DOI={10.1532/HSF98.200344395}, abstractNote={<strong>Background</strong>: Myocor developed a unique system, the<br />Coapsys annuloplasty system, to treat functional mitral<br />regurgitation (MR) without cardiopulmonary bypass (CPB).<br />This study was conducted to test the feasibility of the Coapsys<br />implantation procedure in a canine functional MR model.<br /><strong>Methods</strong>: Functional MR with heart failure was induced<br />in 9 dogs by rapid ventricular pacing (230 beats/min for<br />30 ± 4 days). The Coapsys device, which consists of anterior<br />and posterior epicardial pads connected by a subvalvular<br />chord, was then surgically implanted. Under epicardial<br />echocardiographic guidance, we placed the Coapsys device<br />across the left ventricular chamber using the delivery instrument<br />and needle assembly. We sized the Coapsys device by<br />drawing the posterior leaflet and annulus toward the anterior<br />leaflet with the sizing instrument. Final device size was<br />selected when MR was minimized or eliminated as assessed<br />by 2-dimensional color Doppler echocardiography.<br /><strong>Results</strong>: In all cases, we successfully implanted the Coapsys<br />device without CPB or atriotomy. MR was reduced an<br />average of 2 grades. No adverse events, such as hemodynamic<br />compromise or structural valve damage, were noted.<br /><strong>Conclusion</strong>: Coapsys device implantation was feasible<br />and safe on a beating canine heart. All accessory tools used<br />for device implantation were found useful.}, number={2}, journal={The Heart Surgery Forum}, author={Inoue, Masahiro and McCarthy, Patrick M. and Popovic, Zoran B. and Doi, Kazuyoshi and Schenk, Soren and Nemeh, Hassan and Ootaki, Yoshio and Kopcak, Jr, Michael W. and Dessoffy, Raymond and Thomas, James D. and Fukamachi, Kiyotaka}, year={2005}, month={Jan.}, pages={69-73} }