@article{Guan_Guan_Gu_Li_Lin_Zhou_Xu_Song_Zhang_Wan_2020, title={The Effect of Different Types of Mechanical Circulatory Support on Mortality of Patients after Adult Cardiac Surgery: A Systematic Review and Meta-Analysis: A systematic review and meta-analysis}, volume={23}, url={https://journal.hsforum.com/index.php/HSF/article/view/2979}, DOI={10.1532/hsf.2979}, abstractNote={<p class="p1"><span class="s1"><strong>Objectives:</strong> Sample size may limit the ability of individual studies to detect differences in clinical outcomes between extracorporeal membrane oxygenation (ECMO) alone and ECMO plus intra-aortic balloon pump (IABP) after adult cardiac surgery. Therefore, we undertook a meta-analysis of the best evidence available on the comparison of clinical outcomes of ECMO alone and ECMO plus IABP after adult cardiac surgery.</span></p> <p class="p1"><span class="s1"><strong>Methods:</strong> PubMed, EMBASE, Web of Science, and Cochrane Center Registry of Controlled Trials were searched for studies comparing the use of ECMO alone and ECMO plus IABP after adult cardiac surgery. A meta-analysis and a sensitivity analysis were conducted.</span></p> <p class="p1"><span class="s1"><strong>Results:</strong> Among the 472 screened articles, 24 studies (1302 cases of ECMO plus IABP and 1603 cases of ECMO) were included. A significant relationship between patient risk profile and benefits from IABP plus ECMO was found in terms of the 30-day mortality (odds ratio [OR] 0.75; 95% confidence interval [CI] 0.62 to 0.91; <em>P</em> = .004) with postcardiotomy shock (PCS). However, ECMO alone was associated with lower in-hospital mortality (OR 1.75; 95% CI 1.06 to 3.01; Z = 2.19; <em>P</em> = .03) compared with ECMO plus IABP without PCS.</span></p> <p class="p1"><span class="s1"><strong>Conclusions:</strong> Pooled data show that patients receiving IABP plus ECMO with PCS have lower 30-day mortality than those receiving ECMO also, which in turn show higher 30-day mortality in patients with IABP plus ECMO without PCS. Further randomized studies are warranted to corroborate these observational data.</span></p>}, number={4}, journal={The Heart Surgery Forum}, author={Guan, Zhiyuan and Guan, Xiaoqing and Gu, Kaiyun and Li, Yanqi and Lin, Jin and Zhou, Wenjun and Xu, Ming and Song, Chunli and Zhang, Zhe and Wan, Feng}, year={2020}, month={Jul.}, pages={E537-E545} }