@article{Guan_Zhang_Gu_Wang_Lin_Zhou_Wan_2019, title={Minimally Invasive CABG or Hybrid Coronary Revascularization for Multivessel Coronary Diseases: Which Is Best? A Systematic Review and Metaanalysis: A systematic review and meta-analysis}, volume={22}, url={https://journal.hsforum.com/index.php/HSF/article/view/2499}, DOI={10.1532/hsf.2499}, abstractNote={<p class="p1"><span class="s1"><strong>Objectives:</strong> Minimally invasive coronary revascularization (MICR) involves minimally invasive direct coronary artery bypass grafting (MIDCAB) and robotic-assisted coronary artery bypass grafting (RCABG), and hybrid coronary revascularization (HCR) aims to combine MICR/RCABG on left anterior descending (LAD) and percutaneous coronary interventions (PCI) on non-LAD lesions. We performed a systematic review and metaanalysis to compare clinical outcome after MICR and HCR.</span></p> <p class="p1"><span class="s1"><strong>Methods:</strong> A metaanalysis was carried out through searching PubMed, EMBASE, Web of Science, and Medline for comparative studies evaluating the primary and secondary clinical end points.</span></p> <p class="p1"><span class="s2"><strong>Results:</strong> A systematic literature search identified 8 observational studies that satisfied our inclusion criteria, including being suitable for metaanalysis; the studies were between 1990 and 2018 and included 1084 cases of HCR and 2349 cases of MICR. Metaanalysis of these studies showed that HCR was associated with a reduced need for ICU LOS (WMD –11.46 hours, 95% CI, –18.76 ~ –4.25, <em>P</em> = .02), </span> <span class="s2">to hospital time (WMD –1.34 hours, 95% CI, –2.42 to 0.26, <em>P</em> &lt; .01), and blood transfusion (OR 0.43, 95% CI, 0.31-0.59, <em>P</em> &lt; .00001) than MICR. Comparisons of individual components showed no significant difference in terms of in-hospital mortality, MACCE, shock, myocardial infarction (MI), long-term survival, total variable cost, and surgical complications (including renal failure, chest drainage, bleeding).</span></p> <p class="p1"><span class="s1"><strong>Conclusions:</strong> HCR was noninferior to MICR in terms of in-hospital mortality, MACCE, shock, MI, long-term survival, total variable cost, and surgical complications (including renal failure, chest drainage, bleeding), whereas HCR was associated with a reduced need for ICU LOS, hospital time, and blood transfusion than MICR and less infection than MICR. Further randomized studies are warranted to corroborate these observational data.</span></p>}, number={6}, journal={The Heart Surgery Forum}, author={Guan, Zhiyuan and Zhang, Zhe and Gu, Kaiyun and Wang, Heqing and Lin, Jin and Zhou, Wenjun and Wan, Feng}, year={2019}, month={Dec.}, pages={E493-E502} }