@article{Meguro_Kakizaki_Hashimoto_Yanagisawa_Koitabashi_Kitamura_Ako_2018, title={Early Safety and Efficacy of Sapien 3 20 mm Transcatheter Heart Valve Implantation in Small Japanese Body Size}, volume={21}, url={https://journal.hsforum.com/index.php/HSF/article/view/1918}, DOI={10.1532/hsf.1918}, abstractNote={<p class="p1"><span class="s1"><strong>Background:</strong> Transcatheter aortic valve implantation (TAVI) is effective in treating severe aortic stenosis in inoperable or high-risk surgical patients, however, the little is known about outcomes after Sapien 3 20 mm transcatheter heart valve (THV) implantation. The purpose of this study was to investigate the short term outcomes of Sapien 3 20 mm THV implantation in Japanese people with a small body size.</span></p> <p class="p1"><span class="s1"><strong>Methods:</strong> We retrospectively collected the hospital records of consecutive patients who underwent TAVI using the Sapien 3 20 mm THV between October 2016 and March 2017. Clinical and echocardiographic data from before and one week after TAVI were collected.</span></p> <p class="p1"><span class="s1"><strong>Results:</strong> Six Japanese patients (all female, mean age 89 ± 5 years, body surface area [BSA] 1.29 ± 0.16m<sup>2</sup>) received a Sapien 3 20 mm THV. All the procedures were feasible and successful, and the 30-day mortality rate was 0%. The functional class and the echocardiographic findings significantly improved (aortic valve area, 0.5 ± 0.1 cm<sup>2</sup> to 0.8 ± 0.1cm<sup>2</sup>; mean pressure gradient, 55 ± 15 mmHg to 19 ± 7 mmHg; <br> <em>P</em> = .043, respectively). However, the values of the indexed effective orifice area in all patients after Sapien 3 20 mm </span><span class="s2">THV implantation were less than 0.85 cm<sup>2</sup>/m<sup>2</sup>, suggesting </span><span class="s1">prosthesis-patient mismatch (PPM).</span></p> <p class="p1"><span class="s1"><strong>Conclusions:</strong> The implantation of a Sapien 3 20 mm THV was safe and effective in high surgical risk elderly Japanese patients with a small body size. PPM after Sapien 3 20mm THV may be prevalent among Asians with small body sizes. Careful clinical follow-up will be necessary after Sapien 3 20 mm THV implantation.</span></p>}, number={5}, journal={The Heart Surgery Forum}, author={Meguro, Kentaro and Kakizaki, Ryota and Hashimoto, Takuya and Yanagisawa, Tomoyoshi and Koitabashi, Toshimi and Kitamura, Tadashi and Ako, Junya}, year={2018}, month={Aug.}, pages={E341-E344} }