@article{Carrier_Perrault_Jeanmart_Martineau_Cartier_Pagé_2005, title={Randomized Trial Comparing Off-Pump to On-Pump Coronary Artery Bypass Grafting in High-Risk Patients}, volume={6}, url={https://journal.hsforum.com/index.php/HSF/article/view/1094}, DOI={10.1532/hsf.1094}, abstractNote={<P>Objective: The subset of patients most likely to benefit from off-pump coronary artery bypass grafting (CABG) remains a controversial issue, but the technique has been proposed to decrease postoperative mortality and morbidity. The objective of this study was to compare off-pump to on-pump CABG in patients with known risk factors for mortality and morbidity. </P><P>Methods: Between October 2001 and September 2002, 65 high-risk patients were prospectively randomized to undergo off-pump or on-pump CABG. Recruited patients had at least 3 of the following criteria: age greater than 65 years, high blood pressure, diabetes, serum creatinine greater than 133 3mol/L, left ventricular ejection fraction lower than 45%, chronic pulmonary disease, unstable angina, congestive heart failure, repeat CABG, anemia, and carotid atherosclerosis. Hospital mortality and morbidity were the primary end-points of the study. </P><P>Results: Six patients (9%) crossed over from the original randomized group. Twenty-eight patients averaging 70 ± 8 years of age underwent 3 ± 1 grafts off pump, and 37 patients averaging 70 ± 6 years of age underwent 3.4 ± 1 grafts on pump. Revascularization was considered complete in 21 (75%) of off-pump patients compared to 33 (89%) of on-pump patients (P = .1). There were no hospital deaths in off-pump patients, and 2 patients (5%) undergoing on-pump CABG died early following surgery (P = .2). Two off-pump (7%) compared to 11 on-pump (30%) of patients presented composite end-points including death, neurological injury, renal failure, respiratory failure, and operative myocardial infarction after CABG (P = .02). </P><P>Conclusion: The present study suggests that off-pump CABG, when technically feasible, significantly reduces morbidity following surgery in a group of high-risk patients.</P>}, number={6}, journal={The Heart Surgery Forum}, author={Carrier, Michel and Perrault, Louis P. and Jeanmart, Hugues and Martineau, Raymond and Cartier, Raymond and Pagé, Pierre}, year={2005}, month={Feb.}, pages={E89-E92} }