Early and Midterm Results of Off-Pump Coronary Artery Bypass Grafting without Patient Selection
DOI:
https://doi.org/10.1532/HSF98.20071220Abstract
Background: Many reports have addressed the technical feasibility and early clinical results of off-pump coronary artery bypass grafting (OPCABG). It is uncertain, however, whether OPCABG provides midterm results equivalent to those of conventional CABG.
Methods: At Shiga University of Medical Science Hospital from January 2002 to May 2007, 477 consecutive patients underwent isolated OPCABG myocardial revascularization performed by a single surgeon (T.A.). OPCABG surgery was performed on all patients, with no exclusion criteria. These 477 patients were followed up for time-related events, including death from all causes, cardiac death, myocardial infarction, percutaneous coronary intervention, reoperation, and the combined end-point of cardiac events. Follow-up was completed in 96.0% of the patients (458 of 477).
Results: The number of distal anastomoses per patient was 3.46 ± 0.9, and complete revascularization was achieved in 96.6% of patients. No patient required conversion from off-pump to on-pump surgery. The average operation time was 272 ± 63 minutes. Thirteen patients (2.9%) required reoperation for bleeding. Deep sternal infection occurred in 5 patients (1.1%). One patient (0.2%) had a stroke and 4 patients (0.9%) had perioperative myocardial infarction. Acute renal failure requiring hemodialysis occurred in 10 patients (2.2%). Overall 30-day mortality was 1.1% (5 of 477). Follow-up was completed in 96.0% of patients. Mean follow-up was 3.0 ± 1.3 years. Five-year freedom from death from any cause was 79.1%, freedom from cardiac death 93.4%, and freedom from the combined end-point of cardiac death, myocardial infarction, repeat coronary intervention, and heart failure was 75.8%.
Conclusions: Our results demonstrate the safety of performing OPCABG surgery in all patients, without the use of exclusion criteria. Early and midterm outcomes were acceptable and encouraged continued use of the OPCABG approach in all CABG patients.
References
Arom KV, Flavin TF, Emery RW, et al. 2000. Safety and efficacy of off-pump coronary artery bypass grafting. Ann Thorac Surg 69:704-10.nAtsushi A, Hitoshi H, Akihito T, et al. 2001. Off-pump coronary artery bypass. Jpn J Thorac Cardiovasc Surg 49:67-78.nCalafiore AM, Di Giammarco G, Teodori G, et al. 2005. Bilateral internal thoracic artery grafting with and without cardiopulmonary bypass: six-year clinical outcome. J Thorac Cardiovasc Surg 130:340-5.nCalafiore AM, Dimauro M, Contini M, et al. 2001. Myocardial revascularization with and without cardiopulmonary bypass in multivessel disease: impact of the strategy on early outcome. Ann Thorac Surg 72:456-63.nCleveland JC Jr, Shroyer ALW, Chen AY, et al. 2001. Off-pump coronary artery bypass grafting decreases risk-adjusted mortality and morbidity. Ann Thorac Surg 72:1282-89.nCzerny M, Baumer H, Kilo J, et al. 2001. Complete revascularization in coronary artery bypass grafting with and without cardiopulmonary bypass. Ann Thorac Surg. 71:165-9.nDijk DV, Spoor M, Hijman R, et al. 2007. Cognitive and cardiac outcomes 5 years after off-pump vs on-pump coronary artery bypass graft surgery. JAMA. 297:701-8.nFukui T, Takanashi S, Hosoda Y, et al. 2007. Early and midterm results of off-pump coronary artery bypass grafting. Ann Thorac Surg. 83:115-9.nGundry SR, Romano MA, Shattuck OH, et al. 1998. Seven-year follow-up of coronary artery bypasses performed with and without cardiopulmonary bypass. J Thorac Cardiovasc Surg 115:1273-8.nHannan EL, Racz ML, Walford G, et al. 2005. Long-term outcomes of coronary-artery bypass grafting versus stent implantation. N Engl J Med 352:2174-83.nHannan EL, Wu C, Smith CR, et al. 2007. Off-pump versus on-pump coronary artery bypass graft surgery. Circulation 116:1145-52.nKleisli T, Cheng W, Jacobs MJ, et al. 2005. In the current era, complete revascularization improves survival after coronary artery bypass surgery. J Thorac Cardiovasc Surg. 129:1283-91.nSabik JF, Blackstone EH, Lytle BW, et al. 2004. Equivalent midterm outcomes after off-pump and on-pump coronary surgery. J Thorac Cardiovasc Surg 127:142-8.nShennib H, Endo M, Benhamed O, et al. 2002. Surgical revascularization in patients with poor left ventricular function: on- or off-pump? Ann Thorac Surg 74:1344-7.nSuzuki T, Okabe M, Yasuda F, et al. 2003. Our experiences for off-pump coronary artery bypass grafting to the circumflex system. Ann Thorac Surg. 76:2013-6.nSelnes OA, Grega MA, Bailey MM, et al. 2007. Neurocognitive Outcomes 3 years after coronary artery bypass graft surgery: A controlled study. Ann Thorac Surg. 84: 1885-96.n