Environmental Pollution as a Cause of Papillary Fibroelastoma: Hints for a New Etiological Hypothesis?
Background: Environmental pollution has adverse human health effects, mostly on the respiratory tract but also on the cardiovascular system. Papillary fibroelastomas are exceedingly rare primary cardiac tumors; their pathologic origin remains still elusive.
Case Report: This is a brief report on 3 patients referred for surgical treatment of papillary fibroelastomas in the last 6 months. All patients were born, lived, and worked in a narrow region in Campania that is under active monitoring because of high rates of environmental pollution.
Conclusions: Known mechanisms of cardiovascular damage generated by environmental pollution are cross linked with described papillary fibroelastomas' etiological cascade. Evidence is suggested for a common origin. These results provide intriguing but inconclusive insights into pathophysiological pathways that may link exposure to environmental pollution and development of papillary fibroelastomas.
Pope CA 3rd. 2000. Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who's at risk? Environ Health Perspect 108:713-23.nPope CA 3rd, Burnett RT, Thurston GD, et al. 2004. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation 109:71-7.nChen H, Goldberg MS, Villeneuve PJ. 2008. A systematic review of the relation between long-term exposure to ambient air pollution and chronic diseases. Rev Environ Health 23:243-97.nComba P, Bianchi F, Fazzo L, et al. 2006. Cancer mortality in an area of Campania (Italy) characterized by multiple toxic dumping sites. Ann N Y Acad Sci 1076:449-61.nEdwards FH, Hale D, Cohen A, Thompson L, Pezzella AT, Virmani R. 1991. Primary cardiac valve tumors. Ann Thorac Surg 52:1127-31.nFazzo L, Belli S, Minichilli F, et al. 2008. Cluster analysis of mortality and malformations in the Provinces of Naples and Caserta (Campania Region). Ann Ist Super Sanita 44:99-111.nMariscalco G, Bruno VD, Borsani P, Dominici C, Sala A. 2010. Papillary fibroelastoma: insight to a primary cardiac valve tumor. J Card Surg 25:198-205.nShapiro LM. 2001. Cardiac tumours: diagnosis and management. Heart 85:218-22.n
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