Effect of Dexmedetomidine on The Neuroglobin Expression in Elderly Patients With Minimally Invasive Coronary Artery Bypass Graft Surgery

Authors

  • Yan Gao Department of Anesthesiology, The First Affiliated Hospital of Hebei North University
  • Huidan Yu Department of Ultrasound Medicine, The First Affiliated Hospital of Hebei North University
  • Wenlong Wang Operating Room, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei
  • Yeming Wang
  • Jinliang Teng Department of Anesthesiology, The First Affiliated Hospital of Hebei North University
  • Fulong LI Department of Anesthesiology, The First Affiliated Hospital of Hebei North University

DOI:

https://doi.org/10.1532/hsf.4073

Keywords:

Dexmedetomidine, Neuroglobin, postoperative cognitive dysfunction, Mini mental status examination

Abstract

Background: To study the effect of dexmedetomidine (Dex) on the expression of Neuroglobin (Ngb) and postoperative cognitive function in elderly patients undergoing minimally invasive coronary artery bypass surgery.

Methods: Forty patients, who underwent elective minimally invasive off-pump coronary artery bypass grafting in our hospital from January 2018 to December 2019, were randomly divided into the Dex group (N = 20) and control group (N = 20). Venous blood samples were taken to determine the expression level of Ngb in both groups. Mini mental status examination (MMSE) was used to detect the cognitive function of patients.

Results: The expression level of Ngb in the Dex group was significantly higher than that in the control group at 6h after one-lung ventilation and postoperative 24h (P < .01). The MMSE score of the Dex group was significantly higher than the control group at postoperative 7 days and postoperative 30 days (P < .01). Although with no statistical significance, the MMSE score of the Dex group was higher than the control group at postoperative 90 days (P > .05). The incidence of postoperative cognitive dysfunction (POCD) in the Dex group was significantly lower than that in the control group at postoperative 7 days and postoperative 30 days (P < .05).

Conclusion: Dex used in elderly patients undergoing minimally invasive coronary artery bypass graft surgery can effectively increase the expression level of Ngb and reduce the incidence of POCD.

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Published

2021-09-08

How to Cite

Gao, Y., Yu, H., Wang, W., Wang, Y., Teng, J., & LI, F. (2021). Effect of Dexmedetomidine on The Neuroglobin Expression in Elderly Patients With Minimally Invasive Coronary Artery Bypass Graft Surgery. The Heart Surgery Forum, 24(5), E776-E780. https://doi.org/10.1532/hsf.4073

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Articles