Galectin-3 in Predicting Mortality of Heart Failure: A Systematic Review and Meta-Analysis

Authors

  • Chenxia Wu Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
  • Zhengtian Lv Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
  • Xinyi Li Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
  • Xinbing Zhou Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
  • Wei Mao Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China
  • Min Zhu Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China

DOI:

https://doi.org/10.1532/hsf.3547

Keywords:

galectin-3, heart failure, mortality, meta-analysis

Abstract

Background: In recent years, galectin-3, an inflammatory marker, has been demonstrated to be closely related to cardiac fibrosis and heart failure. The purpose of this systematic review and meta-analysis is to define galectin-3 in predicting mortality of heart failure.

Methods: PubMed, Embase, and the Cochrane Library were searched. A total of 1540 studies were identified, and of these studies, 19 involving 9217 patients were included in our meta-analysis.

Results: The diagnostic hazard ratios of galectin-3 in predicting mortality in chronic heart failure patients was 1.13 (95% CI,:1.07-1.21 ) and 2.17 (95% CI:1.27-3.08) in acute heart failure (HF) patients.

Conclusions: Our meta-analysis shows that elevated levels of galectin-3 are associated with higher mortality in both acute and chronic heart failure patients.

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Published

2021-03-30

How to Cite

Wu, C., Lv, Z., Li, X., Zhou, X., Mao, W., & Zhu, M. (2021). Galectin-3 in Predicting Mortality of Heart Failure: A Systematic Review and Meta-Analysis. The Heart Surgery Forum, 24(2), E327-E332. https://doi.org/10.1532/hsf.3547

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