Surgical Management of Intraoperative Aortic Dissection in Type 3 Loeys-Dietz Syndrome with MYH11 Co-Mutation

Authors

  • Fumiya Yoneyama, MD Department of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan
  • Hideyuki Kato, MD, PhD Department of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan
  • Bryan J. Mathis, PhD Department of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan
  • Yuji Hiramatsu, MD, PhD Department of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan

DOI:

https://doi.org/10.1532/hsf.3533

Keywords:

Intraoperative aortic dissection, Loeys-Dietz syndrome, MYH11 mutation

Abstract

A 57-year-old female with Loeys-Dietz syndrome type 3 and MYH11 gene mutation underwent unexpected intraoperative ascending aortic dissection and subsequent rapid progression of the aortic arch dissecting aneurysm. Intra-surgical contingency plans with regard to aortic dissection and aneurysm should be considered for Loeys-Dietz syndrome, especially with comorbid mutations.

References

Krohg-Sørensen K, Lingaas PS, Lundblad R, et al. 2017. Cardiovascular surgery in Loeys-Dietz syndrome types 1-4. Eur J Cardiothorac Surg. 52:1125-31.

Kumar K, Menkis AH, Jassal DS, Arora RC. 2009. Iatrogenic acute aortic dissection in a patient with Marfan syndrome: unusual site of intimal tear. Interact Cardiovasc Thorac Surg. 8:362-3.

Ikeda Y. 2016. Aortic Aneurysm: Etiopathogenesis and Clinicopathologic Correlations. Ann Vasc Dis. 9:73-9.

Narayan P, Angelini GD, Bryan AJ. 2015. Iatrogenic intraoperative type A aortic dissection following cardiac surgery. Asian Cardiovasc Thorac Ann. 23:31-5.

Takeda N, Komuro I. 2019. Genetic basis of hereditary thoracic aortic aneurysms and dissections. J Cardiol. 74:136-43.

Published

2021-03-03

How to Cite

Yoneyama, F., Kato, H., Mathis, B., & Hiramatsu, Y. (2021). Surgical Management of Intraoperative Aortic Dissection in Type 3 Loeys-Dietz Syndrome with MYH11 Co-Mutation. The Heart Surgery Forum, 24(2), E231-E232. https://doi.org/10.1532/hsf.3533

Issue

Section

Articles